DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME101714 Target: OPRK
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101713 Target: PAR1
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101712 Target: ACVR2B
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101711 Target: ACVR2B
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101710 Target: ACVR2B
Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00
ECD Proteins
SKU: PME101709 Target: ACVR2A
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101700 Target: IL31RA
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101793 Target: TGFB2
Price:10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME101731 Target: sortase A
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101708 Target: ACVR2A
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101707 Target: ACVR2A
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101706 Target: PD-L1
Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME101704 Target: IL11
Price:10μg $82.00 ; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME101703 Target: 4-1BB
Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME101702 Target: 4-1BB
Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME101701 Target: PRAME
Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00
ECD Proteins
SKU: PME101699 Target: IL31RA
Price:10μg $75.00 ; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101698 Target: QRFPR
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101697 Target: NK1R
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
ECD Proteins
SKU: PME101696 Target: CA9
Price:10μg $78.00 ; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME101695 Target: 4-1BB
Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME101694 Target: 4-1BB
Price:10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME101693 Target: 5T4
Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00
ECD Proteins
SKU: PME101692 Target: 5T4
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101691 Target: CA9
Price:10μg $78.00 ; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME101689 Target: SEMA4A
Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00
ECD Proteins
SKU: PME101688 Target: ENPP3
Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101687 Target: ENPP3
Price:10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101686 Target: 5T4
Price:10μg $68.00 ; 50μg $259.00 ; 100 μg $389.00
ECD Proteins
SKU: PME101685 Target: 5T4
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101684 Target: 5T4
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
ECD Proteins
SKU: PME101683 Target: 5T4
Price:10μg $68.00 ; 50μg $259.00 ; 100 μg $389.00