Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101779 adrb1 sp1

ECD Proteins

Human ADRB1 Protein, hFc Tag

SKU:  PME101779     Target:  ADRB1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101778 or1e1 sp1

ECD Proteins

Human OR1E1 Protein, hFc Tag

SKU:  PME101778     Target:  OR1E1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101777 or8u8 sp1

ECD Proteins

Human OR8U8 Protein, hFc Tag

SKU:  PME101777     Target:  OR8U8

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101776 or52d1 sp1

ECD Proteins

Human OR52D1 Protein, hFc Tag

SKU:  PME101776     Target:  OR52D1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101775 or51e2 sp1

ECD Proteins

Human OR51E2 Protein, hFc Tag

SKU:  PME101775     Target:  OR51E2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101774 fabp5 sp1

ECD Proteins

Human FABP5 Protein, His Tag

SKU:  PME101774     Target:  FABP5

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101773 bai1 sp1

ECD Proteins

Human BAI1(1-926) Protein, hFc Tag

SKU:  PME101773     Target:  BAI1

Price:10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme101772 bai1 sp1

ECD Proteins

Human BAI1(31-926) Protein, Flag and Twin-Strep Tag

SKU:  PME101772     Target:  BAI1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101771 cd117 sp1

ECD Proteins

Human CD117 (925-976) Protein, mFc Tag

SKU:  PME101771     Target:  CD117

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101770 gpr6 sp1

ECD Proteins

Human GPR6 Protein, mFc Tag

SKU:  PME101770     Target:  GPR6

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101769 cd117 sp1

ECD Proteins

Human CD117 (925-976) Protein, hFc Tag

SKU:  PME101769     Target:  CD117

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101768 gpr6 sp1

ECD Proteins

Human GPR6 Protein, hFc Tag

SKU:  PME101768     Target:  GPR6

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101767 cblb sp1

ECD Proteins

Human CBLB Protein, Flag Tag

SKU:  PME101767     Target:  CBLB

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101766 netrin 1 sp1

ECD Proteins

Human Netrin-1 Protein, Flag Tag

SKU:  PME101766     Target:  Netrin-1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101765 reg4 sp1

ECD Proteins

Human REG4 Protein, hFc Tag

SKU:  PME101765     Target:  REG4

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101764 procr sp1

ECD Proteins

Human PROCR Protein, hFc Tag

SKU:  PME101764     Target:  PROCR

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101763 nrg4 sp1

ECD Proteins

Human NRG4 Protein, hFc Tag

SKU:  PME101763     Target:  NRG4

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101762 hrh3 sp1

ECD Proteins

Human HRH3 Protein, hFc Tag

SKU:  PME101762     Target:  HRH3

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101761 cd58 sp1

ECD Proteins

Human CD58 Protein, His Tag

SKU:  PME101761     Target:  CD58

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101760 c1qbp sp1

ECD Proteins

Human C1QBP Protein, His Tag

SKU:  PME101760     Target:  C1QBP

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101759 fam171b sp1

ECD Proteins

Human FAM171B Protein, His Tag

SKU:  PME101759     Target:  FAM171B

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101758 erbb4 sp1

ECD Proteins

Human ERBB4 Protein, His Tag

SKU:  PME101758     Target:  ERBB4

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101756 lgr5 sp1

ECD Proteins

Human LGR5(22-561) Protein, hFc Tag

SKU:  PME101756     Target:  LGR5

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101755 nppa sp1

ECD Proteins

Human NPPA Protein, hFc Tag

SKU:  PME101755     Target:  NPPA

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101754 cd43 sp1

ECD Proteins

Human CD43 Protein, His Tag

SKU:  PME101754     Target:  CD43

Price:10μg $85.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101753 scf sp1

ECD Proteins

Human SCF Protein, His Tag

SKU:  PME101753     Target:  SCF

Price:10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101752 epha10 sp1

ECD Proteins

Human EPHA10 Protein, His Tag

SKU:  PME101752     Target:  EPHA10

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101751 anxa2 sp1

ECD Proteins

Human ANXA2 Protein, His Tag

SKU:  PME101751     Target:  ANXA2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101750 timp2 sp1

ECD Proteins

Human TIMP2 Protein, His Tag

SKU:  PME101750     Target:  TIMP2

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101749 f7 sp1

ECD Proteins

Human F7 Protein, Flag Tag

SKU:  PME101749     Target:  F7

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101748 f11 sp1

ECD Proteins

Human F11 Protein, Flag Tag

SKU:  PME101748     Target:  F11

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101746 vegfc sp1

ECD Proteins

Human VEGFC Protein, hFc Tag

SKU:  PME101746     Target:  VEGFC

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00