Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101653 fgf8b sp1

ECD Proteins

Human FGF8b(23-215) Protein, hFc Tag

SKU:  PME101653     Target:  FGF8b

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101645 akt1 sp1

ECD Proteins

Human AKT1 Protein, Flag Tag

SKU:  PME101645     Target:  AKT1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101636 ror2 sp1

ECD Proteins

Human ROR2(146-315) Protein, hFc Tag

SKU:  PME101636     Target:  ROR2

Price:10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101635 ceacam6 sp1

ECD Proteins

Human CEACAM6(233-319) Protein, hFc Tag

SKU:  PME101635     Target:  CEACAM6

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101634 ceacam6 sp1

ECD Proteins

Human CEACAM6(143-239) Protein, hFc Tag

SKU:  PME101634     Target:  CEACAM6

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101633 ceacam6 sp1

ECD Proteins

Human CEACAM6(35-144) Protein, hFc Tag

SKU:  PME101633     Target:  CEACAM6

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101624 fgf1 sp1

ECD Proteins

Human FGF1 Protein, hFc Tag

SKU:  PME101624     Target:  FGF1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101623 cdh17 sp1

ECD Proteins

Human CDH17(668-787) Protein, hFc Tag

SKU:  PME101623     Target:  CDH17

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101622 cd117 sp1

ECD Proteins

Human CD117(411-524) Protein, hFc Tag

SKU:  PME101622     Target:  CD117

Price:10μg $85.00; 50μg $330.00 ; 100 μg $500.00

elisa-PME100066 GPRC5D hFc His ELISA Fig2

ECD Proteins

Human GPRC5D Protein, hFc-His Tag

SKU:  PME100066     Target:  GPRC5D

Price: 10μg $99.00 ; 50μg $309.00 ; 100 μg $466.00

sp-PME100559 GPRC5D Fig.3 Elisa 2

ECD Proteins

Human GPRC5D Protein, mFc Tag

SKU:  PME100559     Target:  GPRC5D

Price: 10μg $99.00 ; 50μg $309.00 ; 100 μg $466.00

elisa-PME100677 GPRC5D hFc→DM91 ELISA Fig2

ECD Proteins

Human GPRC5D Protein, hFc Tag

SKU:  PME100677     Target:  GPRC5D

Price: 10μg $99.00 ; 50μg $309.00 ; 100 μg $466.00

sp-pme101621 cd117 sp1

ECD Proteins

Human CD117(309-412) Protein, hFc Tag

SKU:  PME101621     Target:  CD117

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101620 cd117 sp1

ECD Proteins

Human CD117(206-316) Protein, hFc Tag

SKU:  PME101620     Target:  CD117

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101619 b7 h7 sp1

ECD Proteins

Human B7-H7(223-344) Protein, hFc Tag

SKU:  PME101619     Target:  B7-H7

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101618 b7 h7 sp1

ECD Proteins

Human B7-H7(132-234) Protein, hFc Tag

SKU:  PME101618     Target:  B7-H7

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101617 b7 h7 sp1

ECD Proteins

Human B7-H7(23-137) Protein, hFc Tag

SKU:  PME101617     Target:  B7-H7

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101616 cdh3 sp1

ECD Proteins

Human CDH3(547-654) Protein, hFc Tag

SKU:  PME101616     Target:  CDH3

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101615 cdh3 sp1

ECD Proteins

Human CDH3(441-546) Protein, hFc Tag

SKU:  PME101615     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme101614 cdh3 sp1

ECD Proteins

Human CDH3(329-440) Protein, hFc Tag

SKU:  PME101614     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme101613 cdh3 sp1

ECD Proteins

Human CDH3(216-328) Protein, hFc Tag

SKU:  PME101613     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme101612 fgf2 sp1

ECD Proteins

Human FGF2 Protein, Flag Tag

SKU:  PME101612     Target:  FGF2

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101611 ngf sp1

ECD Proteins

Human NGF(19-241) Protein, hFc Tag

SKU:  PME101611     Target:  NGF

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101610 acvr2b sp1

ECD Proteins

Human ACVR2B Protein, mFc Tag

SKU:  PME101610     Target:  ACVR2B

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101609 acvr2a sp1

ECD Proteins

Human ACVR2A Protein, mFc Tag

SKU:  PME101609     Target:  ACVR2A

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101608 cdh17 sp1

ECD Proteins

Human CDH17(23-128) Protein, hFc Tag

SKU:  PME101608     Target:  CDH17

Price: 10μg $68.00; 50μg $259.00 ; 100 μg $389.00

sp-pme101607 cdh1 sp1

ECD Proteins

Human CDH1(594-709) Protein, hFc Tag

SKU:  PME101607     Target:  CDH1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101606 nectin 4 sp1

ECD Proteins

Human Nectin-4(238-349) Protein, hFc Tag

SKU:  PME101606     Target:  Nectin-4

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101605 nectin 4 sp1

ECD Proteins

Human Nectin-4(145-247) Protein, hFc Tag

SKU:  PME101605     Target:  Nectin-4

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101604 nectin 4 sp1

ECD Proteins

Human Nectin-4(32-147) Protein, hFc Tag

SKU:  PME101604     Target:  Nectin-4

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101603 cd117 sp1

ECD Proteins

Human CD117(113-211) Protein, hFc Tag

SKU:  PME101603     Target:  CD117

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme101602 cd117 sp1

ECD Proteins

Human CD117(26-120) Protein, hFc Tag

SKU:  PME101602     Target:  CD117

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00