Nanodiscs-based Full-length Membrane Protein

What are Nanodiscs?

Nanodiscs provide a membrane-like environment that stabilizes membrane proteins (MPs) in a near-native state, overcoming major challenges in MP expression, purification, and functional analysis. Full-length multi-pass membrane proteins are often difficult to express, prone to misfolding, and easily destabilized by traditional detergents. By improving protein stability, activity, and structural integrity, Nanodiscs enable more reliable structural studies, functional assays, and drug screening. Platforms such as MSP, Synthetic, and PeptiNanodiscs further support diverse membrane protein research and accelerate drug discovery.

For more details about applications of Nanodiscs in MPs research, you can explore this blog…

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ADGRE1 ADRA1D AQP4-M1
AQP5 CCR5 CLDN3
CRHR2 GPR37 GRM2
MC4R PROKR1 TSHR
Biotinylated LGR5
Click to View All of The Full-length MPs
Types Validation Data Hot Catagories FAQs

Why Nanodiscs for MPs?

Nanodiscs are discoidal lipid bilayers stabilized by scaffold proteins or synthetic polymers. They maintain:

  • Native folding of GPCRs, ion channels, transporters, and multi-pass receptors
  • High monodispersity suitable for cryo-EM and NMR
  • Improved solubility and stability without detergents
  • Reliable performance in binding, functional, and biophysical assays
  • Enhanced batch consistency, critical for drug screening workflows

Why Choose Us?

  • Large catalog of GPCRs, ion channels, transporters, and oncology-related membrane proteins (300+ In Stock)
  • Detergent-Free or Minimal-Detergent Final Format: Maintains natural conformation and eliminates the instability caused by traditional detergent micelles.
  • High Purity & High Monodispersity: Verified through SDS-PAGE, SEC-HPLC, and functional assays (ELISA, SPR, ligand binding, or antibody binding)
  • Fast global delivery for research labs and drug discovery teams

Types of Nanodisc-based MPs

As mentioned before, Nanodiscs can be classified based on the stabilizing agents used. The major formats are MSP Nanodiscs, Synthetic Nanodiscs, and PeptiNanodiscs. To fully leverage Nanodiscs, DIMA BIOTECH uses the HEK293 system to produce recombinant membrane proteins that closely mimic their natural forms, supporting faster and more reliable drug discovery. Currently, DIMA BIOTECH has rich experience in developing full-length multi-pass membrane proteins with Synthetic Nanodiscs and PeptiNanodiscs.

*Search by gene name, alias, UniProt ID, or product SKU. Can’t find what you need? Contact us for custom development.

A Polymer-Based Solution for Multipass TPs, Covering 500+ Targets Included in GPCR, Ion Channel, Transportors etc.

All Synthetic Nanodisc

Human SCAP full length protein-synthetic nanodisc

SKU:  FLP100498     Target:  SCAP     Tag:  C-Flag Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

Human ABCG2 full length protein-synthetic nanodisc

SKU:  FLP100497     Target:  ABCG2     Tag:  C-Flag Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

Human CLDN18.2-Strep full length protein-synthetic nanodisc

SKU:  FLP120014     Target:  CLDN18.2     Tag:  C-Flag&Strep Tag

Expression Host:  HEK293

Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00

Human FFAR4-Strep full length protein-synthetic nanodisc

SKU:  FLP120238     Target:  FFAR4     Tag:  C-Flag&Strep Tag

Expression Host:  HEK293

Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00

Biotinylated Human CD4 full length protein-synthetic nanodisc

SKU:  FLP100160B     Target:  CD4     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00

Biotinylated Human CXCR4 full length protein-synthetic nanodisc

SKU:  FLP100074B     Target:  CXCR4     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00

Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc

SKU:  FLP100014B     Target:  CLDN18.2     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00

Human SLC34A2 full length protein-synthetic nanodisc

SKU:  FLP100496     Target:  SLC34A2     Tag:  C-Flag Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

A Peptide-Based Solution for Multipass TPs, Stabilizing Membrane Proteins for Cell-Based Applications.

All PeptiNanodiscs

Human TSHR-Strep full length protein-PeptiNanodisc

SKU:  FLP420045     Target:  TSHR     Tag:  C-Flag&Strep Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4360.00 ; 100 μg $7920.00

Human TSHR full length protein-PeptiNanodisc

SKU:  FLP400045     Target:  TSHR     Tag:  C-Flag Tag

Expression Host:  HEK293

Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00

Human AQP5 full length protein-PeptiNanodisc

SKU:  FLP400158     Target:  AQP5     Tag:  C-Flag Tag

Expression Host:  HEK293

Price: 10 μg $990.00 ; 50 μg $4840.00 ; 100 μg $8800.00

Biotinylated Human CD19 full length protein-PeptiNanodisc

SKU:  FLP400499B     Target:  CD19     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $1089.00 ; 50 μg $5324.00 ; 100 μg $9680.00

Biotinylated Human CCR2 full length protein-PeptiNanodisc

SKU:  FLP400028B     Target:  CCR2     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $1089.00 ; 50 μg $5324.00 ; 100 μg $9680.00

Biotinylated Human CCR8 full length protein-PeptiNanodisc

SKU:  FLP400037B     Target:  CCR8     Tag:  C-Flag&Avi Tag

Expression Host:  HEK293

Price: 10 μg $1089.00 ; 50 μg $5324.00 ; 100 μg $9680.00

Human CCR8-Strep full length protein-PeptiNanodisc

SKU:  FLP420037     Target:  CCR8     Tag:  C-Flag&Strep Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4360.00 ; 100 μg $7920.00

Human CLDN18.1-Strep full length protein-PeptiNanodisc

SKU:  FLP420503     Target:  CLDN18.1     Tag:  C-Flag&Strep Tag

Expression Host:  HEK293

Price: 10 μg $900.00 ; 50 μg $4360.00 ; 100 μg $7920.00

Validation Data of Nanodisc-based MPs

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human GPR75-synthetic nanodisc (FLP120031) can bind Loaded Human GPR75 mAb (DMC100368) with an affinity constant of 5.02nM.

Human CLDN18.2-synthetic nanodisc (FLP120014) can bind loaded Human CLDN18.2 mAb (BME100075) with an affinity constant of 8.09nM.

GPRC5D PeptiNanodisc (Cat.No.FLP400011) and G4S-PE protein were used to detect the positivity rate of GPRC5D CAR-T cells.

Explore Other Full-length Membrane Protein Solutions

Hot Catagories of Nanodisc-based MPs

the structure of GPCRs

G protein-coupled receptors (GPCRs)

More Details
the structure of ion channel-1-1

Ion Channels

More Details

FAQs

1. Q: Which materials are used for Nanodisc Proteins?

A: We utilize synthetic nanodiscs that are internally synthesized within our company. However, specific details regarding the composition of our nanodiscs are proprietary and confidential.

2. Q: Is it possible to purchase empty nanodiscs?

A: Currently, we do not have empty nanodiscs available for purchase. However, we do offer nanodiscs designed for specific target proteins.

3. Q: Has the function of the protein/nanodisc been tested after lyophilization and dissolving?

A: Yes, all our nanodiscs undergo comprehensive lyophilization and testing procedures. The data presented on our website is derived from the protein after the lyophilization and reconstitution process. The products are shipped at room temperature after lyophilization.

4. Q: Do you offer additional testing for standard Nanodisc products?

A: Our Nanodisc proteins have been verified using an anti-Flag tag antibody. We can attempt verification using other antibodies if suitable ones are available. However, please note that for some products, we may not have an appropriate antibody in our inventory. If you have any suggestions, kindly share them with us so that we can explore the possibility of working with the recommended antibody.

Explore all the FAQs of Nanodisc-based proteins

Citation

[1] Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)