the structure of GPL1R

GLP1R Target: Not Just for Blood Sugar Control and Weight Loss, but a Potential Breakthrough for Anti-Nausea in Weight Loss Medications

Currently, the most popular GLP1-based monotherapy, Semaglutide, controls blood sugar by promoting insulin secretion and induces a lasting sense of fullness to reduce appetite. However, this drug can cause side effects such as nausea and vomiting, which can affect patient adherence to the treatment. On July 10, 2024, Kuei-Pin Huang and colleagues published a paper […]

Blog , 2024-08-19
The structure of GIPR

GIP Receptor (GIPR): A Novel Target for Glycemic Control and Weight Loss

On February 27, 2024, Viking Therapeutics announced the results of their Phase IIa clinical study for VK2735, a dual GLP-1R/GIPR agonist for obesity. The results showed a maximum weight loss of 13.1% after 13 weeks of treatment. Following this news, Viking’s stock surged by 121%. The company has received written feedback from the FDA and […]

Blog , 2024-08-08
The typical structure of ADAMs

The Fate of ADAM9 ADCs: What Lies Ahead After AbbVie’s Decision?

In March 2024, AbbVie announced its decision to terminate the development of IMGC936 in collaboration with MacroGenics, citing that the clinical phase I trial results did not meet the expected safety and efficacy targets. IMGC936 was an antibody-drug conjugate (ADC) targeting ADAM9, initially developed through a partnership between ImmunoGen and MacroGenics, with each holding a […]

Blog 2024-08-01

Discover DIMA at Membrane Protein Paris 2024

Membrane proteins are essential for cell functions such as maintaining cellular physiological processes, playing crucial roles in substance transport, signal transduction, and cell recognition. They constitute approximately 25% of the total proteome encoded by the human genome. Currently, membrane protein targets account for over 60% of known drug targets and over 90% of antibody drug […]

News 2024-07-26
The structures of SEZ6 family

SEZ6 – A Potential Target for ADC Therapy in Small Cell Lung Cancer

Seizure related 6 homolog (SZE6) is a transmembrane protein discovered on the surface of selected neuronal lineage cells. Its expression is limited in normal tissues but highly expressed in small cell lung cancer (SCLC), making it an ideal target for ADC (Antibody-Drug Conjugate) therapy. AbbVie presented early data on their SEZ6 ADC drug, ABBV-706, in […]

Blog 2024-07-24
The structure of classical Cadherins

CDH6 ADC: Promising Results for Ovarian Cancer Treatment!

In March 2024, a preclinical study titled “Raludotatug Deruxtecan, a CDH6-Targeting Antibody–Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models” was published in Molecular Cancer Therapeutics. This study demonstrated that Raludotatug Deruxtecan, developed by Daiichi Sankyo, is effective against human ovarian and kidney cancer models. Additionally, […]

Blog 2024-07-17
The structure of tissue factor (TF)

Tissue Factor (TF/CD142) – A Potential New Horizon for Pancreatic Cancer Therapy?

At the 2024 ASCO Annual Meeting, one of the highlights was the MRG004A-001 study conducted by Professor Yu Xianjun’s team, marking a milestone in the exploration of escalating doses of MRG004A, an ADC drug targeting tissue factor TF/CD142. Carried out in the United States and China, the study’s findings are significant. Among 12 evaluated pancreatic […]

Blog 2024-07-04
The structure of STEAP1

STEAP1 – A Therapeutic Target for Prostate Cancer

At the 2024 ASCO Annual Meeting, HANGZHOU DAC BIOTECHNOLOGY (abbreviated as DAC Biotech) presented preclinical data on their STEAP1 ADC, DXC008. This ADC targets both STEAP1 and PSMA, showing high affinity for STEAP1 and moderate affinity for PSMA. Preclinical data demonstrated that a single dose of 1 mpk produced durable anti-tumor responses in xenograft models […]

Blog 2024-07-03
The process of Nectin-4 regulating cancer development through PI3K/AKT pathway and promoting angiogenesis after hypoxia

Nectin-4: A Promising Target in Antibody-Drug Conjugate (ADC) Therapy

During the 2024 ASCO conference, Professor Zhang Jian of Fudan University’s Cancer Hospital unveiled the Phase I/II clinical trial outcomes for 9MW2821, an ADC drug targeting Nectin-4, designed to combat advanced solid tumors. The drug demonstrated promising results, particularly in treating urothelial carcinoma, cervical cancer, esophageal cancer, and triple-negative breast cancer. Concurrently, CSPS showcased their […]

Blog 2024-06-13

Emerging Trends: ADC Drug Targets to Watch at ASCO 2024

The 2024 American Society of Clinical Oncology Annual Meeting (ASCO 2024) will take place in Chicago, USA, from May 31st to June 4th. As a major event in the cancer treatment community, it will reveal many important clinical research outcomes and the latest innovations. Antibody-drug conjugates (ADCs), which cleverly combine targeted antibody therapies with powerful […]

Blog 2024-05-23