Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101582 ror1 sp1

ECD Proteins

Human ROR1(148-311) Protein, hFc Tag

SKU:  PME101582     Target:  ROR1

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101581 ror1 sp1

ECD Proteins

Human ROR1(30-164) Protein, hFc Tag

SKU:  PME101581     Target:  ROR1

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101580 il36g sp1

ECD Proteins

Human IL36G Protein, hFc Tag

SKU:  PME101580     Target:  IL36G

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101579 il36a sp1

ECD Proteins

Human IL36A Protein, hFc Tag

SKU:  PME101579     Target:  IL36A

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101578 dll3 sp1

ECD Proteins

Human DLL3(27-175) Protein, N-MBP Tag and C-10×His tag

SKU:  PME101578     Target:  DLL3

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101577 b7 h4 sp1

ECD Proteins

Human B7-H4(147-259) Protein, hFc Tag

SKU:  PME101577     Target:  B7-H4

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101576 b7 h4 sp1

ECD Proteins

Human B7-H4(25-152) Protein, hFc Tag

SKU:  PME101576     Target:  B7-H4

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101575 ceacam5 sp1

ECD Proteins

Human CEACAM5(496-592) Protein, hFc Tag

SKU:  PME101575     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101574 ceacam5 sp1

ECD Proteins

Human CEACAM5(411-500) Protein, hFc Tag

SKU:  PME101574     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101573 ceacam5 sp1

ECD Proteins

Human CEACAM5(316-417) Protein, hFc Tag

SKU:  PME101573     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101572 ceacam5 sp1

ECD Proteins

Human CEACAM5(233-322) Protein, hFc Tag

SKU:  PME101572     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101571 ceacam5 sp1

ECD Proteins

Human CEACAM5(145-239) Protein, hFc Tag

SKU:  PME101571     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101570 ceacam5 sp1

ECD Proteins

Human CEACAM5(35-144) Protein, hFc Tag

SKU:  PME101570     Target:  CEACAM5

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101568 fcgr1a sp1

ECD Proteins

Human FCGR1A Protein, His Tag

SKU:  PME101568     Target:  FCGR1A

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101561 g csf sp1

ECD Proteins

Human G-CSF Protein, hFc Tag

SKU:  PME101561     Target:  G-CSF

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101560 fcgr1a sp1

ECD Proteins

Human FCGR1A Protein, hFc Tag

SKU:  PME101560     Target:  FCGR1A

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101559 apoa1 sp1

ECD Proteins

Human APOA1 Protein, His Tag

SKU:  PME101559     Target:  APOA1

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101558 cd19 sp1

ECD Proteins

Human CD19(M75V,R76S,F85S) Protein, hFc Tag

SKU:  PME101558     Target:  CD19

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101557 cd19 sp1

ECD Proteins

Human CD19(M75I,L82V,F83L) Protein, hFc Tag

SKU:  PME101557     Target:  CD19

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101556 clm5 sp1

ECD Proteins

Human CLM5 Protein, hFc Tag

SKU:  PME101556     Target:  CLM5

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101555 pvrig sp1

ECD Proteins

Human PVRIG(53-150) Protein, hFc Tag

SKU:  PME101555     Target:  PVRIG

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101554 hsd17b10 sp1

ECD Proteins

Human HSD17B10 Protein, Flag Tag

SKU:  PME101554     Target:  HSD17B10

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101553 AKT1 sp1

ECD Proteins

Human AKT1(409-480) Protein, hFc Tag

SKU:  PME101553     Target:  AKT1

Price: 10μg $79.00 ; 50μg $281.00 ; 100μg $422.00

sp-pme101552 rnf133 sp1

ECD Proteins

Human RNF133 Protein, hFc Tag

SKU:  PME101552     Target:  RNF133

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101567 cdh17 sp1

ECD Proteins

Human CDH17(668-777) Protein, hFc Tag

SKU:  PME101567     Target:  CDH17

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101566 cdh17 sp1

ECD Proteins

Human CDH17(450-566) Protein, hFc Tag

SKU:  PME101566     Target:  CDH17

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101565 cdh17 sp1

ECD Proteins

Human CDH17(341-449) Protein, hFc Tag

SKU:  PME101565     Target:  CDH17

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101564 cdh17 sp1

ECD Proteins

Human CDH17(245-340) Protein, hFc Tag

SKU:  PME101564     Target:  CDH17

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme101563 cdh17 sp1

ECD Proteins

Human CDH17(129-244) Protein, hFc Tag

SKU:  PME101563     Target:  CDH17

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101562 cdh17 sp1

ECD Proteins

Human CDH17(30-128) Protein, hFc Tag

SKU:  PME101562     Target:  CDH17

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme c100070 muc1 sp1

ECD Proteins

Cynomolgus MUC1(380-500) Protein, mFc Tag

SKU:  PME-C100070     Target:  MUC1

Price:10μg $81.00 ; 50μg $296.00 ; 100μg $444.00

sp-pme c100069 muc1 sp1

ECD Proteins

Cynomolgus MUC1(380-500) Protein, hFc Tag

SKU:  PME-C100069     Target:  MUC1

Price:10μg $81.00 ; 50μg $296.00 ; 100μg $444.00