Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme c100068 muc1 sp1

ECD Proteins

Cynomolgus MUC1(24-504) Protein, His Tag

SKU:  PME-C100068     Target:  MUC1

Price:10μg $81.00 ; 50μg $296.00 ; 100μg $444.00

sp-pme c100067 crtam sp1

ECD Proteins

Cynomolgus CRTAM Protein, His Tag

SKU:  PME-C100067     Target:  CRTAM

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101551 acvr2b sp1

ECD Proteins

Human ACVR2B Protein, hFc Tag

SKU:  PME101551     Target:  ACVR2B

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101550 acvr2a sp1

ECD Proteins

Human ACVR2A Protein, hFc Tag

SKU:  PME101550     Target:  ACVR2A

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101549 apoe2 sp1

ECD Proteins

Human APOE2 Protein, His Tag

SKU:  PME101549     Target:  APOE2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101548 apoe4 sp1

ECD Proteins

Human APOE4 Protein, His Tag

SKU:  PME101548     Target:  APOE4

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101547 crtam sp1

ECD Proteins

Human CRTAM Protein, mFc Tag

SKU:  PME101547     Target:  CRTAM

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101546 crtam sp1

ECD Proteins

Human CRTAM Protein, hFc Tag

SKU:  PME101546     Target:  CRTAM

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101545 cadm1 sp1

ECD Proteins

Human CADM1 Protein, mFc Tag

SKU:  PME101545     Target:  CADM1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101544 cadm1 sp1

ECD Proteins

Human CADM1 Protein, hFc Tag

SKU:  PME101544     Target:  CADM1

Price:10μg $79.00 ; 50μg $281.00 ; 100μg $422.00

sp-pme101543 mmp9 sp1

ECD Proteins

Human MMP9(32-488) Protein, hFc Tag

SKU:  PME101543     Target:  MMP9

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101542 dll1 sp1

ECD Proteins

Human DLL1 Protein, His Tag

SKU:  PME101542     Target:  DLL1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101541 kir2dl1 sp1

ECD Proteins

Human KIR2DL1 Protein, His Tag

SKU:  PME101541     Target:  KIR2DL1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101540 clec1a sp1

ECD Proteins

Human CLEC1A Protein, His Tag

SKU:  PME101540     Target:  CLEC1A

Price:10μg $75.00 ; 50μg $274.00 ; 100μg $411.00

sp-pme101539 ly6e sp1

ECD Proteins

Human LY6E Protein, hFc Tag

SKU:  PME101539     Target:  LY6E

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101538 fgf19 sp1

ECD Proteins

Human FGF19 Protein, hFc Tag

SKU:  PME101538     Target:  FGF19

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101537 tnfsf15 sp1

ECD Proteins

Human TNFSF15 Protein, His Tag

SKU:  PME101537     Target:  TNFSF15

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101536 alpl sp1

ECD Proteins

Human ALPL Protein, His Tag

SKU:  PME101536     Target:  ALPL

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101535 cd3e sp1

ECD Proteins

Human CD3E Protein, His Tag

SKU:  PME101535     Target:  CD3E

Price:10μg $75.00 ; 50μg $274.00 ; 100μg $411.00

sp-pme101534 znrf3 sp1

ECD Proteins

Human ZNRF3 Protein, hFc Tag

SKU:  PME101534     Target:  ZNRF3

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101533 adamts13 sp1

ECD Proteins

Human ADAMTS13 Protein, Flag Tag

SKU:  PME101533     Target:  ADAMTS13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101531 alpi sp1

ECD Proteins

Human ALPI Protein, His Tag

SKU:  PME101531     Target:  ALPI

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101530 steap1 sp1

ECD Proteins

Human STEAP1 Protein, hFc Tag

SKU:  PME101530     Target:  STEAP1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101529 fcrl1 sp1

ECD Proteins

Human FCRL1 Protein, hFc Tag

SKU:  PME101529     Target:  FCRL1

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101527 ifnar2 sp1

ECD Proteins

Human IFNAR2 Protein, His Tag

SKU:  PME101527     Target:  IFNAR2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101526 sparc sp1

ECD Proteins

Human SPARC Protein, His Tag

SKU:  PME101526     Target:  SPARC

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101525 ednrb sp1

ECD Proteins

Human EDNRB Protein, hFc Tag

SKU:  PME101525     Target:  EDNRB

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101524 cfd sp1

ECD Proteins

Human CFD Protein, His Tag

SKU:  PME101524     Target:  CFD

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101523 tshr sp1

ECD Proteins

Human TSHR(23-410) Protein, hFc Tag

SKU:  PME101523     Target:  TSHR

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101522 cd3g sp1

ECD Proteins

Human CD3G Protein, hFc Tag

SKU:  PME101522     Target:  CD3G

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101521 vegfd sp1 1

ECD Proteins

Human VEGFD Protein, hFc Tag

SKU:  PME101521     Target:  VEGFD

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101520 pth1r sp1 1

ECD Proteins

Human PTH1R Protein, hFc Tag

SKU:  PME101520     Target:  PTH1R

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00