Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

pages-416107bc534d939 1

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

pages-cvsdvdfffffb 1

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme c100078 slitrk6 sp1

ECD Proteins

Cynomolgus SLITRK6 Protein, His Tag

SKU:  PME-C100078     Target:  SLITRK6

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme c100077 cdh3 sp1

ECD Proteins

Cynomolgus CDH3 Protein, His Tag

SKU:  PME-C100077     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme c100076 cdcp1 sp1

ECD Proteins

Cynomolgus CDCP1 Protein, His Tag

SKU:  PME-C100076     Target:  CDCP1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme c100075 liv 1 sp1

ECD Proteins

Cynomolgus LIV-1 Protein, hFc Tag

SKU:  PME-C100075     Target:  LIV-1

Price: 10μg $137.00 ; 50μg $513.00 ; 100 μg $752.00

sp-pme c100074 her2 sp1

ECD Proteins

Cynomolgus Her2 Protein, His Tag

SKU:  PME-C100074     Target:  Her2

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme c100073 gpc3 sp1

ECD Proteins

Cynomolgus GPC3(510-559) Protein, hFc Tag

SKU:  PME-C100073     Target:  GPC3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme c100072 gpc3 sp1

ECD Proteins

Cynomolgus GPC3(24-552) Protein, hFc Tag

SKU:  PME-C100072     Target:  GPC3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme c100071 gpc3 sp1

ECD Proteins

Cynomolgus GPC3(24-552) Protein, His Tag

SKU:  PME-C100071     Target:  GPC3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100119 slitrk6 sp1

ECD Proteins

Mouse SLITRK6 Protein, His Tag

SKU:  PME-M100119     Target:  SLITRK6

Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme m100118 cdh3 sp1

ECD Proteins

Mouse CDH3 Protein, His Tag

SKU:  PME-M100118     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme m100117 gpc3 sp1

ECD Proteins

Mouse GPC3(510-559) Protein, hFc Tag

SKU:  PME-M100117     Target:  GPC3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100116 acvr2b sp1

ECD Proteins

Mouse ACVR2B Protein, hFc Tag

SKU:  PME-M100116     Target:  ACVR2B

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme m100115 acvr2a sp1

ECD Proteins

Mouse ACVR2A Protein, hFc Tag

SKU:  PME-M100115     Target:  ACVR2A

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101601 msp2n2 sp1

ECD Proteins

Human MSP2N2 Protein, His Tag

SKU:  PME101601     Target:  MSP2N2

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101600 msp1d1 sp1

ECD Proteins

Human MSP1D1 Protein, His Tag

SKU:  PME101600     Target:  MSP1D1

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101599 msp1d1 sp1

ECD Proteins

Human MSP1D1(del H5) Protein, His Tag

SKU:  PME101599     Target:  MSP1D1

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101598 il31ra sp1

ECD Proteins

Human IL31RA Protein, mFc Tag

SKU:  PME101598     Target:  IL31RA

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101597 il31ra sp1

ECD Proteins

Human IL31RA Protein, hFc Tag

SKU:  PME101597     Target:  IL31RA

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101596 cdh3 sp1

ECD Proteins

Human CDH3(108-215) Protein, hFc Tag

SKU:  PME101596     Target:  CDH3

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme101595 ror2 sp1

ECD Proteins

Human ROR2(304-403) Protein, hFc Tag

SKU:  PME101595     Target:  ROR2

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101594 ror2 sp1

ECD Proteins

Human ROR2(34-168) Protein, hFc Tag

SKU:  PME101594     Target:  ROR2

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101593 il31 sp1

ECD Proteins

Human IL31 Protein, His Tag

SKU:  PME101593     Target:  IL31

Price: 10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101592 pd l1 sp1

ECD Proteins

Human PD-L1(128-238) Protein, hFc Tag

SKU:  PME101592     Target:  PD-L1

Price: 10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00

sp-pme101591 pd l1 sp1

ECD Proteins

Human PD-L1(19-132) Protein, hFc Tag

SKU:  PME101591     Target:  PD-L1

Price: 10μg $96.00 ; 50μg $370.00 ; 100 μg $555.00

sp-pme101590 b7 h3 sp1

ECD Proteins

Human B7-H3(140-248) Protein, hFc Tag

SKU:  PME101590     Target:  B7-H3

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101589 b7 h3 sp1

ECD Proteins

Human B7-H3(29-144) Protein, hFc Tag

SKU:  PME101589     Target:  B7-H3

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101588 itpripl1 sp1

ECD Proteins

Human ITPRIPL1 Protein, hFc Tag

SKU:  PME101588     Target:  ITPRIPL1

Price: 10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101587 axl sp1

ECD Proteins

Human AXL(332-451) Protein, hFc Tag

SKU:  PME101587     Target:  AXL

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101586 axl sp1

ECD Proteins

Human AXL(223-335) Protein, hFc Tag

SKU:  PME101586     Target:  AXL

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101585 axl sp1

ECD Proteins

Human AXL(129-226) Protein, hFc Tag

SKU:  PME101585     Target:  AXL

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101584 axl sp1

ECD Proteins

Human AXL(27-138) Protein, hFc Tag

SKU:  PME101584     Target:  AXL

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101583 axl sp1

ECD Proteins

Human AXL(26-92) Protein, hFc Tag

SKU:  PME101583     Target:  AXL

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00