Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101519 gpbar1 sp1 1

ECD Proteins

Human GPBAR1 Protein, hFc Tag

SKU:  PME101519     Target:  GPBAR1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101518 slc44a4 sp1 1

ECD Proteins

Human SLC44A4 Protein, hFc Tag

SKU:  PME101518     Target:  SLC44A4

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101517 lamp5 sp1 1

ECD Proteins

Human LAMP5 Protein, His Tag

SKU:  PME101517     Target:  LAMP5

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101516 ifngr1 sp1 1

ECD Proteins

Human IFNGR1 Protein, His Tag

SKU:  PME101516     Target:  IFNGR1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101515 dpep3 sp1

ECD Proteins

Human DPEP3 Protein, His Tag

SKU:  PME101515     Target:  DPEP3

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101514 trhr sp1

ECD Proteins

Human TRHR Protein, hFc Tag

SKU:  PME101514     Target:  TRHR

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101513 or1a1 sp1

ECD Proteins

Human OR1A1 Protein, hFc Tag

SKU:  PME101513     Target:  OR1A1

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101512 gpa33 sp1

ECD Proteins

Human GPA33 Protein, His Tag

SKU:  PME101512     Target:  GPA33

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101511 cd73 sp1

ECD Proteins

Human CD73 Protein, His Tag

SKU:  PME101511     Target:  CD73

Price:10μg $137.00 ; 50μg $513.00 ; 100 μg $752.00

sp-pme101510 cd2 sp1

ECD Proteins

Human CD2 Protein, His Tag

SKU:  PME101510     Target:  CD2

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101509 b4galt1 sp1

ECD Proteins

Human B4GALT1 Protein, His Tag

SKU:  PME101509     Target:  B4GALT1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101508 osm sp1

ECD Proteins

Human OSM Protein, His Tag

SKU:  PME101508     Target:  OSM

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101507 il1r2 sp1

ECD Proteins

Human IL1R2 Protein, mFc Tag

SKU:  PME101507     Target:  IL1R2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101506 il1a sp1

ECD Proteins

Human IL1A Protein, mFc Tag

SKU:  PME101506     Target:  IL1A

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101503 il1r2 sp1

ECD Proteins

Human IL1R2 Protein, hFc Tag

SKU:  PME101503     Target:  IL1R2

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101502 il1ra sp1

ECD Proteins

Human IL1RA Protein, His Tag

SKU:  PME101502     Target:  IL1RA

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101501 ca12 sp1

ECD Proteins

Human CA12 Protein, His Tag

SKU:  PME101501     Target:  CA12

Price:10μg $71.00 ; 50μg $259.00 ; 100μg $389.00

sp-pme101497 ceacam5 sp1

ECD Proteins

Human CEACAM5(589-685) Protein, hFc Tag

SKU:  PME101497     Target:  CEACAM5

Price:10μg $87.00 ; 50μg $318.00 ; 100μg $478.00

sp-pme101496 ceacam5 sp1

ECD Proteins

Human CEACAM5(496-685) Protein, His Tag

SKU:  PME101496     Target:  CEACAM5

Price:10μg $87.00 ; 50μg $318.00 ; 100μg $478.00

sp-pme101489 nkg2c sp1

ECD Proteins

Human NKG2C Protein, hFc Tag

SKU:  PME101489     Target:  NKG2C

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101488 igf2 sp1

ECD Proteins

Human IGF2 Protein, hFc Tag

SKU:  PME101488     Target:  IGF2

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101487 ccl7 sp1

ECD Proteins

Human CCL7 Protein, hFc Tag

SKU:  PME101487     Target:  CCL7

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101486 adam17 sp1

ECD Proteins

Human ADAM17 Protein, hFc Tag

SKU:  PME101486     Target:  ADAM17

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00

sp-pme101485 il29 sp1

ECD Proteins

Human IL29 Protein, hFc Tag

SKU:  PME101485     Target:  IL29

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101484 il7 sp1

ECD Proteins

Human IL7 Protein, hFc Tag

SKU:  PME101484     Target:  IL7

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101483 lair2 sp1

ECD Proteins

Human LAIR2 Protein, hFc Tag

SKU:  PME101483     Target:  LAIR2

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101482 he4 sp1

ECD Proteins

Human HE4 Protein, hFc Tag

SKU:  PME101482     Target:  HE4

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101481 efna4 sp1

ECD Proteins

Human EFNA4 Protein, hFc Tag

SKU:  PME101481     Target:  EFNA4

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101480 dkk3 sp1

ECD Proteins

Human DKK3 Protein, hFc Tag

SKU:  PME101480     Target:  DKK3

Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00

sp-pme101479 efna1 sp1

ECD Proteins

Human EFNA1 Protein, hFc Tag

SKU:  PME101479     Target:  EFNA1

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101478 cd105 sp1

ECD Proteins

Human CD105 Protein, His Tag

SKU:  PME101478     Target:  CD105

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme101477 ccl22 sp1

ECD Proteins

Human CCL22 Protein, hFc Tag

SKU:  PME101477     Target:  CCL22

Price:10μg $100.00 ; 50μg $358.00 ; 100μg $528.00