Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101467 itgav itgb5 sp1

ECD Proteins

Human ITGAV and ITGB5 Heterodimer Protein, His Tag and hFc Tag

SKU:  PME101467     Target:  ITGAV and ITGB5

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

sp-pme c100066 dll3 sp1

ECD Proteins

Cynomolgus DLL3(350-488) Protein, hFc Tag

SKU:  PME-C100066     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme c100065 dll3 sp1

ECD Proteins

Cynomolgus DLL3(426-488) Protein, hFc Tag

SKU:  PME-C100065     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme c100064 dll3 sp1

ECD Proteins

Cynomolgus DLL3(388-488) Protein, hFc Tag

SKU:  PME-C100064     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme c100063 dll3 sp1 1

ECD Proteins

Cynomolgus DLL3(309-488) Protein, hFc Tag

SKU:  PME-C100063     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme c100062 dll3 sp1 1

ECD Proteins

Cynomolgus DLL3(272-488) Protein, His Tag

SKU:  PME-C100062     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme c100061 fcrl5 sp1 1

ECD Proteins

Cynomolgus FCRL5 Protein, His Tag

SKU:  PME-C100061     Target:  FCRL5

Price: 10μg $100.00; 50μg $358.00 ; 100μg $528.00

sp-pme m100114 folr1 sp1

ECD Proteins

Mouse FOLR1 Protein, His Tag

SKU:  PME-M100114     Target:  FOLR1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100113 fcrl5 sp1

ECD Proteins

Mouse FCRL5 Protein, His Tag

SKU:  PME-M100113     Target:  FCRL5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101532 dll3 sp1 1

ECD Proteins

Human DLL3(176-215) Protein, hFc Tag

SKU:  PME101532     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101505 dll3 sp1 1

ECD Proteins

Human DLL3(428-492) Protein, hFc Tag

SKU:  PME101505     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101504 dll3 sp1 1

ECD Proteins

Human DLL3(311-492) Protein, hFc Tag

SKU:  PME101504     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101499 dll3 sp1 1

ECD Proteins

Human DLL3(390-492) Protein, hFc Tag

SKU:  PME101499     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101498 dll3 sp1

ECD Proteins

Human DLL3(352-492) Protein, hFc Tag

SKU:  PME101498     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101491 vegf165 sp1

ECD Proteins

Human VEGF165 Protein, hFc Tag

SKU:  PME101491     Target:  VEGF165

Price: 10μg $90.00; 50μg $320.00 ; 100μg $480.00

sp-pme101490 vegf121 sp1 1

ECD Proteins

Human VEGF121 Protein, hFc Tag

SKU:  PME101490     Target:  VEGF121

Price: 10μg $90.00; 50μg $320.00 ; 100μg $480.00

sp-pme100742 adamts13 sp1

ECD Proteins

Human ADAMTS13 Protein, His Tag

SKU:  PME100742     Target:  ADAMTS13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme f100002 il31ra sp1

ECD Proteins

Feline IL31RA Protein, mFc Tag

SKU:  PME-F100002     Target:  IL31RA

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme d100010 il31ra sp1

ECD Proteins

Canine IL31RA Protein, mFc Tag

SKU:  PME-D100010     Target:  IL31RA

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme c100060 bcma sp1

ECD Proteins

Cynomolgus BCMA Protein, hFc Tag

SKU:  PME-C100060     Target:  BCMA

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme c100059 ror2 sp1

ECD Proteins

Cynomolgus ROR2 Protein, N-His Tag

SKU:  PME-C100059     Target:  ROR2

Price: 10μg $112.00; 50μg $409.00 ; 100 μg $614.00

sp-pme c100058 ror2 sp1

ECD Proteins

Cynomolgus ROR2 Protein, C-His Tag

SKU:  PME-C100058     Target:  ROR2

Price: 10μg $112.00; 50μg $409.00 ; 100 μg $614.00

sp-pme c100057 trop2 sp1

ECD Proteins

Cynomolgus Trop2 Protein, His Tag

SKU:  PME-C100057     Target:  Trop2

Price: 10μg $104.00 ; 50μg $386.00 ; 100 μg $570.00

sp-pme c100026 muc1 sp1

ECD Proteins

Cynomolgus MUC1(254-373) Protein, His Tag

SKU:  PME-C100026     Target:  MUC1

Price: 10μg $104.00 ; 50μg $386.00 ; 100 μg $570.00

sp-pme m100112 cdh6 sp1

ECD Proteins

Mouse CDH6 Protein, His Tag

SKU:  PME-M100112     Target:  CDH6

Price: 10μg $104.00 ; 50μg $386.00 ; 100 μg $570.00

sp-pme101528 hgf sp1

ECD Proteins

Human HGF(1-728) Protein, hFc Tag

SKU:  PME101528     Target:  HGF

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101500 il1ra sp1

ECD Proteins

Human IL1RA Protein, mFc Tag

SKU:  PME101500     Target:  IL1RA

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101476 cd300c sp1

ECD Proteins

Human CD300C Protein, hFc Tag

SKU:  PME101476     Target:  CD300C

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101475 folr3 sp1

ECD Proteins

Human FOLR3 Protein, His Tag

SKU:  PME101475     Target:  FOLR3

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101474 efnb1 sp1

ECD Proteins

Human EFNB1 Protein, His Tag

SKU:  PME101474     Target:  EFNB1

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101473 dll4 sp1

ECD Proteins

Human DLL4 Protein, His Tag

SKU:  PME101473     Target:  DLL4

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101472 tpo sp1

ECD Proteins

Human TPO Protein, His Tag

SKU:  PME101472     Target:  TPO

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00