Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101471 aplnr sp1

ECD Proteins

Human APLNR Protein, hFc Tag

SKU:  PME101471     Target:  APLNR

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101470 gpr84 sp1

ECD Proteins

Human GPR84 Protein, hFc Tag

SKU:  PME101470     Target:  GPR84

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101465 cxcl14 sp1

ECD Proteins

Human CXCL14 Protein, hFc Tag

SKU:  PME101465     Target:  CXCL14

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101464 ccl19 sp1

ECD Proteins

Human CCL19 Protein, hFc Tag

SKU:  PME101464     Target:  CCL19

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101463 f9 sp1

ECD Proteins

Human F9 Protein, His Tag

SKU:  PME101463     Target:  F9

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101462 f10 sp1

ECD Proteins

Human F10 Protein, His Tag

SKU:  PME101462     Target:  F10

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101461 ccl17 sp1

ECD Proteins

Human CCL17 Protein, hFc Tag

SKU:  PME101461     Target:  CCL17

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101460 ntsr1 sp1

ECD Proteins

Human NTSR1 Protein, hFc Tag

SKU:  PME101460     Target:  NTSR1

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101459 clec10a sp1

ECD Proteins

Human CLEC10A Protein, hFc Tag

SKU:  PME101459     Target:  CLEC10A

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101458 uts2r sp1

ECD Proteins

Human UTS2R Protein, hFc Tag

SKU:  PME101458     Target:  UTS2R

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101457 fshb sp1

ECD Proteins

Human FSHB Protein, hFc Tag

SKU:  PME101457     Target:  FSHB

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101456 ngal sp1

ECD Proteins

Human NGAL Protein, hFc Tag

SKU:  PME101456     Target:  NGAL

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101455 npy sp1

ECD Proteins

Human NPY Protein, hFc Tag

SKU:  PME101455     Target:  NPY

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101454 gip sp1

ECD Proteins

Human GIP Protein, hFc Tag

SKU:  PME101454     Target:  GIP

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101453 hmgb1 sp1

ECD Proteins

Human HMGB1 Protein, His Tag

SKU:  PME101453     Target:  HMGB1

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101452 c6 sp1

ECD Proteins

Human C6 Protein, His Tag

SKU:  PME101452     Target:  C6

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101451 cadm3 sp1

ECD Proteins

Human CADM3 Protein, His Tag

SKU:  PME101451     Target:  CADM3

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101450 ephb3 sp1

ECD Proteins

Human EPHB3 Protein, His Tag

SKU:  PME101450     Target:  EPHB3

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101449 pomc sp1

ECD Proteins

Human POMC Protein, His Tag

SKU:  PME101449     Target:  POMC

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101448 mog sp1

ECD Proteins

Human MOG Protein, hFc Tag

SKU:  PME101448     Target:  MOG

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101446 ccl24 sp1

ECD Proteins

Human CCL24 Protein, hFc Tag

SKU:  PME101446     Target:  CCL24

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101445 cxcl10 sp1

ECD Proteins

Human CXCL10 Protein, hFc Tag

SKU:  PME101445     Target:  CXCL10

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme101444 ror1 sp1

ECD Proteins

Human ROR1(838-937) Protein, hFc Tag

SKU:  PME101444     Target:  ROR1

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101443 her3 sp1

ECD Proteins

Human HER3(1243-1342) Protein, hFc Tag

SKU:  PME101443     Target:  HER3

Price: 10μg $100.00; 50μg $358.00 ; 100 μg $528.00

sp-pme101442 tim3 sp1

ECD Proteins

Human TIM3 Protein, hFc Tag

SKU:  PME101442     Target:  TIM3

Price: 10μg $118.00; 50μg $429.00 ; 100 μg $645.00

sp-pme101441 mapt sp1

ECD Proteins

Human MAPT Protein, His Tag

SKU:  PME101441     Target:  MAPT

Price: 10μg $96.00; 50μg $335.00 ; 100 μg $500.00

sp-pme101440 pedf sp1

ECD Proteins

Human PEDF Protein, His Tag

SKU:  PME101440     Target:  PEDF

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101439 apoe sp1

ECD Proteins

Human APOE Protein, His Tag

SKU:  PME101439     Target:  APOE

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101438 c9 sp1

ECD Proteins

Human C9 Protein, His Tag

SKU:  PME101438     Target:  C9

Price: 10μg $96.00; 50μg $335.00 ; 100 μg $500.00

sp-pme101437 cd209 sp1

ECD Proteins

Human CD209 Protein, His Tag

SKU:  PME101437     Target:  CD209

Price: 10μg $96.00; 50μg $335.00 ; 100 μg $500.00

sp-pme101436 cmklr1 sp1

ECD Proteins

Human CMKLR1 Protein, hFc Tag

SKU:  PME101436     Target:  CMKLR1

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101435 cd300a sp1

ECD Proteins

Human CD300A Protein, hFc Tag

SKU:  PME101435     Target:  CD300A

Price: 10μg $90.00; 50μg $320.00 ; 100 μg $480.00