Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-PME100358 MUC16 Fig.1 SDS PAGE 1

ECD Proteins

Human MUC16(13810-14451) Protein, His Tag

SKU:  PME100358     Target:  MUC16

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101409 MET Fig.1 SDS PAGE 1

ECD Proteins

Human MET Protein, hFc Tag

SKU:  PME101409     Target:  MET

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101357 MICAa3 Fig.1 SDS PAGE 1

ECD Proteins

Human MICAa3 Protein, His Tag

SKU:  PME101357     Target:  MICAa3

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101356 MICAa3 Fig.1 SDS PAGE 1

ECD Proteins

Human MICAa3 Protein, mFc Tag

SKU:  PME101356     Target:  MICAa3

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101355 APLN Fig.1 SDS PAGE 1

ECD Proteins

Human APLN Protein, hFc Tag

SKU:  PME101355     Target:  APLN

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101354 F2RL3 Fig.1 SDS PAGE 1

ECD Proteins

Human F2RL3 Protein, hFc Tag

SKU:  PME101354     Target:  F2RL3

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101353 GPR132 Fig.1 SDS PAGE 1

ECD Proteins

Human GPR132 Protein, hFc Tag

SKU:  PME101353     Target:  GPR132

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101352 IL25 Fig.1 SDS PAGE 1

ECD Proteins

Human IL25 Protein, hFc Tag

SKU:  PME101352     Target:  IL25

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101351 CD62E Fig.1 SDS PAGE 1

ECD Proteins

Human CD62E Protein, His Tag

SKU:  PME101351     Target:  CD62E

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101350 CD161 Fig.1 SDS PAGE 1

ECD Proteins

Human CD161 Protein, hFc Tag

SKU:  PME101350     Target:  CD161

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101349 TREML1 Fig.1 SDS PAGE 1

ECD Proteins

Human TREML1 Protein, hFc Tag

SKU:  PME101349     Target:  TREML1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101348 CFH Fig.1 SDS PAGE 1

ECD Proteins

Human CFH Protein, His Tag

SKU:  PME101348     Target:  CFH

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101347 C5 Fig.1 SDS PAGE 1

ECD Proteins

Human C5 Protein, His Tag

SKU:  PME101347     Target:  C5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101346 TREML2 Fig.1 SDS PAGE 1

ECD Proteins

Human TREML2 Protein, His Tag

SKU:  PME101346     Target:  TREML2

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101345 LEPR Fig.1 SDS PAGE 1

ECD Proteins

Human LEPR Protein, His Tag

SKU:  PME101345     Target:  LEPR

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101344 APOH Fig.1 SDS PAGE 1

ECD Proteins

Human APOH Protein, His Tag

SKU:  PME101344     Target:  APOH

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101343 CX3CL1 Fig.1 SDS PAGE 1

ECD Proteins

Human CX3CL1 Protein, His Tag

SKU:  PME101343     Target:  CX3CL1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101342 C2 Fig.1 SDS PAGE 1

ECD Proteins

Human C2 Protein, His Tag

SKU:  PME101342     Target:  C2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101341 MAG Fig.1 SDS PAGE 1

ECD Proteins

Human MAG Protein, His Tag

SKU:  PME101341     Target:  MAG

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101340 MFAP4 Fig.1 SDS PAGE 1

ECD Proteins

Human MFAP4 Protein, His Tag

SKU:  PME101340     Target:  MFAP4

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101339 AOC3 Fig.1 SDS PAGE 1

ECD Proteins

Human AOC3 Protein, His Tag

SKU:  PME101339     Target:  AOC3

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101338 MSR1 Fig.1 SDS PAGE 1

ECD Proteins

Human MSR1 Protein, His Tag

SKU:  PME101338     Target:  MSR1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101337 FGFR2 Fig.1 SDS PAGE 1

ECD Proteins

Human FGFR2c Protein, His Tag

SKU:  PME101337     Target:  FGFR2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101336 KIR3DL3 Fig.1 SDS PAGE 1

ECD Proteins

Human KIR3DL3 Protein, His Tag

SKU:  PME101336     Target:  KIR3DL3

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101335 NTRK2 Fig.1 SDS PAGE 1

ECD Proteins

Human NTRK2 Protein, His Tag

SKU:  PME101335     Target:  NTRK2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101334 FGFR1 Fig.1 SDS PAGE 1

ECD Proteins

Human FGFR1 Protein, His Tag

SKU:  PME101334     Target:  FGFR1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101333 RTN4R Fig.1 SDS PAGE 1

ECD Proteins

Human RTN4R Protein, His Tag

SKU:  PME101333     Target:  RTN4R

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101332 CCL24 Fig.1 SDS PAGE 1

ECD Proteins

Human CCL24 Protein, hFc Tag

SKU:  PME101332     Target:  CCL24

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101331 PIP Fig.1 SDS PAGE 1

ECD Proteins

Human PIP Protein, hFc Tag

SKU:  PME101331     Target:  PIP

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME100344 MERTK Fig.1 SDS PAGE 1

ECD Proteins

Human MERTK Protein, His Tag

SKU:  PME100344     Target:  MERTK

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME100199 CDH17 Fig.1 SDS PAGE 1

ECD Proteins

Human CDH17(567-667) Protein, hFc Tag

SKU:  PME100199     Target:  CDH17

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100102 TNFSF15 Fig.1 SDS PAGE 1

ECD Proteins

Mouse TNFSF15 Protein, hFc Tag

SKU:  PME-M100102     Target:  TNFSF15

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00