Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-PME101393 DR6 Fig.1 SDS PAGE 1

ECD Proteins

Human DR6 Protein, His Tag

SKU:  PME101393     Target:  DR6

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101392 FCN1 Fig.1 SDS PAGE 1

ECD Proteins

Human FCN1 Protein, His Tag

SKU:  PME101392     Target:  FCN1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101391 FCRL5 Fig.1 SDS PAGE 1

ECD Proteins

Human FCRL5(752-834) Protein, mFc Tag

SKU:  PME101391     Target:  FCRL5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101390 FCRL5 Fig.1 SDS PAGE 1

ECD Proteins

Human FCRL5(752-834) Protein, hFc Tag

SKU:  PME101390     Target:  FCRL5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101389 CSPG4 Fig.1 SDS PAGE 1

ECD Proteins

Human CSPG4(1538-2221) Protein, hFc Tag

SKU:  PME101389     Target:  CSPG4

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101388 PRLR Fig.1 SDS PAGE 1

ECD Proteins

Human PRLR Protein, His Tag

SKU:  PME101388     Target:  PRLR

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101387 CD28 Fig.1 SDS PAGE 1

ECD Proteins

Human CD28 Protein, His Tag

SKU:  PME101387     Target:  CD28

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101386 ITGAVITGB6 Fig.1 SDS PAGE 1

ECD Proteins

Human ITGAV and ITGB6 Heterodimer Protein, His Tag and hFc Tag

SKU:  PME101386     Target:  ITGAV and ITGB6

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101385 CSPG4 Fig.1 SDS PAGE 1

ECD Proteins

Human CSPG4(1538-2221) Protein, mFc Tag

SKU:  PME101385     Target:  CSPG4

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101384 CDH17 Fig.1 SDS PAGE 1

ECD Proteins

Human CDH17(567-667) Protein, mFc Tag

SKU:  PME101384     Target:  CDH17

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101380 CD22 Fig.1 SDS PAGE 1

ECD Proteins

Human CD22(417-678) Protein, mFc Tag

SKU:  PME101380     Target:  CD22

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101379 CD22 Fig.1 SDS PAGE 1

ECD Proteins

Human CD22(417-678) Protein, hFc Tag

SKU:  PME101379     Target:  CD22

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101378 ITGB6 Fig.1 SDS PAGE 1

ECD Proteins

Human ITGB6 Protein, hFc Tag

SKU:  PME101378     Target:  ITGB6

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101377 RAMP1 Fig.1 SDS PAGE 1

ECD Proteins

Human RAMP1 Protein, mFc Tag

SKU:  PME101377     Target:  RAMP1

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101376 CGRPR Fig.1 SDS PAGE 1

ECD Proteins

Human CGRPR Protein, mFc Tag

SKU:  PME101376     Target:  CGRPR

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101375 CGRPR Fig.1 SDS PAGE 1

ECD Proteins

Human CGRPR Protein, hFc Tag

SKU:  PME101375     Target:  CGRPR

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101373 CCN2 Fig.1 SDS PAGE 1

ECD Proteins

Human CCN2 Protein, hFc Tag

SKU:  PME101373     Target:  CCN2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101372 GDF8 Fig.1 SDS PAGE 1

ECD Proteins

Human GDF8 Protein, hFc Tag

SKU:  PME101372     Target:  GDF8

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101371 BCMA Fig.1 SDS PAGE 1

ECD Proteins

Human BCMA(42-54) Protein, mFc Tag

SKU:  PME101371     Target:  BCMA

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101370 BCMA Fig.1 SDS PAGE 1

ECD Proteins

Human BCMA(22-54) Protein, mFc Tag

SKU:  PME101370     Target:  BCMA

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101369 BCMA Fig.1 SDS PAGE 1

ECD Proteins

Human BCMA(22-42) Protein, mFc Tag

SKU:  PME101369     Target:  BCMA

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101368 BCMA Fig.1 SDS PAGE 1

ECD Proteins

Human BCMA(1-42) Protein, mFc Tag

SKU:  PME101368     Target:  BCMA

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101367 BCMA Fig.1 SDS PAGE 1

ECD Proteins

Human BCMA(1-22) Protein, mFc Tag

SKU:  PME101367     Target:  BCMA

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101366 LRP5 Fig.1 SDS PAGE 1

ECD Proteins

Human LRP5 Protein, hFc Tag

SKU:  PME101366     Target:  LRP5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101365 PRL Fig.1 SDS PAGE 1

ECD Proteins

Human PRL Protein, hFc Tag

SKU:  PME101365     Target:  PRL

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101364 APO 1 Fig.1 SDS PAGE 1

ECD Proteins

Human TNFRSF6 Protein, hFc Tag

SKU:  PME101364     Target:  TNFRSF6

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101363 IL3 Fig.1 SDS PAGE 1

ECD Proteins

Human IL3 Protein, hFc Tag

SKU:  PME101363     Target:  IL3

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101362 MMP8 Fig.1 SDS PAGE 1

ECD Proteins

Human MMP8 Protein, His Tag

SKU:  PME101362     Target:  MMP8

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-PME101361 MADCAM1 Fig.1 SDS PAGE 1

ECD Proteins

Human MADCAM1 Protein, His Tag

SKU:  PME101361     Target:  MADCAM1

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101360 OSCAR Fig.1 SDS PAGE 1

ECD Proteins

Human OSCAR Protein, His Tag

SKU:  PME101360     Target:  OSCAR

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101359 ST2 Fig.1 SDS PAGE 1

ECD Proteins

Human ST2 Protein, His Tag

SKU:  PME101359     Target:  ST2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101358 PDGFRA Fig.1 SDS PAGE 1

ECD Proteins

Human PDGFRA Protein, His Tag

SKU:  PME101358     Target:  PDGFRA

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00