Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-PME M100101 IGF 1R Fig.1 SDS PAGE 1

ECD Proteins

Mouse IGF-1R Protein, His Tag

SKU:  PME-M100101     Target:  IGF-1R

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100100 IL6 Fig.1 SDS PAGE 1

ECD Proteins

Mouse IL6 Protein, hFc Tag

SKU:  PME-M100100     Target:  IL6

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100099 PD 1 Fig.1 SDS PAGE 1

ECD Proteins

Mouse PD-1 Protein, hFc Tag

SKU:  PME-M100099     Target:  PD-1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100098 CDH17 Fig.1 SDS PAGE 1

ECD Proteins

Mouse CDH17 Protein, His Tag

SKU:  PME-M100098     Target:  CDH17

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100097 ROR2 Fig.1 SDS PAGE 1

ECD Proteins

Mouse ROR2 Protein, His Tag

SKU:  PME-M100097     Target:  ROR2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100096 IGF1 Fig.1 SDS PAGE 1

ECD Proteins

Mouse IGF1 Protein, hFc Tag

SKU:  PME-M100096     Target:  IGF1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100095 CD70 Fig.1 SDS PAGE 1

ECD Proteins

Mouse CD70 Protein, hFc Tag

SKU:  PME-M100095     Target:  CD70

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100094 AXL Fig.1 SDS PAGE 1

ECD Proteins

Mouse AXL Protein, His Tag

SKU:  PME-M100094     Target:  AXL

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100093 CGRP Fig.1 SDS PAGE 1

ECD Proteins

Mouse CGRP Protein, hFc Tag

SKU:  PME-M100093     Target:  CGRP

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100092 AFP Fig.1 SDS PAGE 1

ECD Proteins

Mouse AFP Protein, His Tag

SKU:  PME-M100092     Target:  AFP

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100091 HistoneH1.2 Fig.1 SDS PAGE 1

ECD Proteins

Mouse HistoneH1.2 Protein, hFc Tag

SKU:  PME-M100091     Target:  HistoneH1.2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100090 TSLP Fig.1 SDS PAGE 1

ECD Proteins

Mouse TSLP Protein, hFc Tag

SKU:  PME-M100090     Target:  TSLP

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100089 5T4 Fig.1 SDS PAGE 1

ECD Proteins

Mouse 5T4 Protein, His Tag

SKU:  PME-M100089     Target:  5T4

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100088 IL11RA Fig.1 SDS PAGE 1

ECD Proteins

Mouse IL11RA Protein, His Tag

SKU:  PME-M100088     Target:  IL11RA

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100087 GUCY2C Fig.1 SDS PAGE 1

ECD Proteins

Mouse GUCY2C Protein, His Tag

SKU:  PME-M100087     Target:  GUCY2C

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100086 TNFRSF1B Fig.1 SDS PAGE 1

ECD Proteins

Mouse TNFRSF1B Protein, His Tag

SKU:  PME-M100086     Target:  TNFRSF1B

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100085 CXADR Fig.1 SDS PAGE 1

ECD Proteins

Mouse CXADR Protein, His Tag

SKU:  PME-M100085     Target:  CXADR

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100084 EPHA2 Fig.1 SDS PAGE 1

ECD Proteins

Mouse EPHA2 Protein, His Tag

SKU:  PME-M100084     Target:  EPHA2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100083 SEZ6 Fig.1 SDS PAGE 1

ECD Proteins

Mouse SEZ6 Protein, His Tag

SKU:  PME-M100083     Target:  SEZ6

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100082 ICAM1 Fig.1 SDS PAGE 1

ECD Proteins

Mouse ICAM1 Protein, His Tag

SKU:  PME-M100082     Target:  ICAM1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100081 CD45 Fig.1 SDS PAGE 1

ECD Proteins

Mouse CD45 Protein, His Tag

SKU:  PME-M100081     Target:  CD45

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME M100080 TREM2 Fig.1 SDS PAGE 1

ECD Proteins

Mouse TREM2 Protein, hFc Tag

SKU:  PME-M100080     Target:  TREM2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100079 CD24 Fig.1 SDS PAGE 1

ECD Proteins

Mouse CD24 Protein, hFc Tag

SKU:  PME-M100079     Target:  CD24

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME M100078 B7 H4 Fig.1 SDS PAGE 1

ECD Proteins

Mouse B7-H4 Protein, His Tag

SKU:  PME-M100078     Target:  B7-H4

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME M100077 PD L1 Fig.1 SDS PAGE 1

ECD Proteins

Mouse PD-L1 Protein, hFc Tag

SKU:  PME-M100077     Target:  PDL1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101400 PLA2R1 Fig.1 SDS PAGE 1

ECD Proteins

Human PLA2R1(21-164) Protein, hFc Tag

SKU:  PME101400     Target:  PLA2R1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101399 PLA2R1 Fig.1 SDS PAGE 1

ECD Proteins

Human PLA2R1(21-521+1097-1246) Protein, His Tag

SKU:  PME101399     Target:  PLA2R1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101398 PLA2R1 Fig.1 SDS PAGE 1

ECD Proteins

Human PLA2R1(21-164+223-359+1097-1246) Protein, His Tag

SKU:  PME101398     Target:  PLA2R1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101397 PLA2R1 Fig.1 SDS PAGE 1 1

ECD Proteins

Human PLA2R1 Protein, His Tag

SKU:  PME101397     Target:  PLA2R1

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101330 IGF1 Fig.1 SDS PAGE 1

ECD Proteins

Human IGF1 Protein, hFc Tag

SKU:  PME101330     Target:  IGF1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101381 HBSAG Fig.1 SDS PAGE 1

ECD Proteins

Hepatitis B virus HBSAG Protein, hFc Tag

SKU:  PME101381     Target:  HBSAG

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101329 WFDC1 Fig.1 SDS PAGE 1

ECD Proteins

Human WFDC1 Protein, hFc Tag

SKU:  PME101329     Target:  WFDC1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00