Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-PME101272 HAMP Fig.1 SDS PAGE 1

ECD Proteins

Human HAMP(60-84) Protein, hFc Tag

SKU:  PME101272     Target:  HAMP

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101271 HAMP Fig.1 SDS PAGE 1

ECD Proteins

Human HAMP(65-84) Protein, hFc Tag

SKU:  PME101271     Target:  HAMP

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101270 TMEM219 Fig.1 SDS PAGE 1

ECD Proteins

Human TMEM219 Protein, hFc Tag

SKU:  PME101270     Target:  TMEM219

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101269 GLP1R Fig.1 SDS PAGE 1

ECD Proteins

Human GLP1R Protein, hFc Tag

SKU:  PME101269     Target:  GLP1R

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101268 GRPR Fig.1 SDS PAGE 1

ECD Proteins

Human GRPR Protein, hFc Tag

SKU:  PME101268     Target:  GRPR

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101267 GIPR Fig.1 SDS PAGE 1

ECD Proteins

Human GIPR Protein, hFc Tag

SKU:  PME101267     Target:  GIPR

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101266 IL12AIL12B Fig.1 SDS PAGE 1

ECD Proteins

Human IL12A and IL12B Heterodimer Protein, hFc Tag and His Tag

SKU:  PME101266     Target:  IL12A and IL12B

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101265 TNFRSF1B Fig.1 SDS PAGE 1

ECD Proteins

Human TNFRSF1B Protein, His Tag

SKU:  PME101265     Target:  TNFRSF1B

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101264 LRP10 Fig.1 SDS PAGE 1

ECD Proteins

Human LRP10 Protein, His Tag

SKU:  PME101264     Target:  LRP10

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101263 LRRN1 Fig.1 SDS PAGE 1

ECD Proteins

Human LRRN1 Protein, His Tag

SKU:  PME101263     Target:  LRRN1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101262 CLEC4A Fig.1 SDS PAGE 1

ECD Proteins

Human CLEC4A Protein, hFc Tag

SKU:  PME101262     Target:  CLEC4A

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101261 MRGPRX2 Fig.1 SDS PAGE 1

ECD Proteins

Human MRGPRX2 Protein, hFc Tag

SKU:  PME101261     Target:  MRGPRX2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101260 IGHE Fig.1 SDS PAGE 1

ECD Proteins

Human IGHE Protein, His Tag

SKU:  PME101260     Target:  IgHE

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101258 VSIG1 Fig.1 SDS PAGE 1

ECD Proteins

Human VSIG1 Protein, His Tag

SKU:  PME101258     Target:  VSIG1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101257 ICAM3 Fig.1 SDS PAGE 1

ECD Proteins

Human ICAM3 Protein, His Tag

SKU:  PME101257     Target:  ICAM3

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101256 FCRL2 Fig.1 SDS PAGE 1

ECD Proteins

Human FCRL2 Protein, His Tag

SKU:  PME101256     Target:  FCRL2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101036 CALCA Fig.1 SDS PAGE 1

ECD Proteins

Human CALCA(85-141) Protein, hFc Tag

SKU:  PME101036     Target:  CALCA

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME100317 KIR2DL1 Fig.1 SDS PAGE 1

ECD Proteins

Human KIR2DL1 Protein, hFc Tag

SKU:  PME100843     Target:  KIR2DL1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101255 GPNMB Fig.1 SDS PAGE 1

ECD Proteins

Human GPNMB Protein, His Tag

SKU:  PME101255     Target:  GPNMB

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101254 IL23R Fig.1 SDS PAGE 1

ECD Proteins

Human IL23R Protein, His Tag

SKU:  PME101254     Target:  IL23R

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101253 KREMEN2 Fig.1 SDS PAGE 1

ECD Proteins

Human KREMEN2 Protein, His Tag

SKU:  PME101253     Target:  KREMEN2

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101252 LAIR1 Fig.1 SDS PAGE 1

ECD Proteins

Human LAIR1 Protein, hFc Tag

SKU:  PME101252     Target:  LAIR1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101251 LY6H Fig.1 SDS PAGE 1

ECD Proteins

Human LY6H Protein, hFc Tag

SKU:  PME101251     Target:  LY6H

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101250 IL19 Fig.1 SDS PAGE 1

ECD Proteins

Human IL19 Protein, hFc Tag

SKU:  PME101250     Target:  IL19

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101249 ninj1 sp1

ECD Proteins

Human NINJ1 Protein, hFc Tag

SKU:  PME101249     Target:  NINJ1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101248 IL20RA Fig.1 SDS PAGE 1

ECD Proteins

Human IL20RA Protein, hFc Tag

SKU:  PME101248     Target:  IL20RA

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101245 DKK1 Fig.1 SDS PAGE 1

ECD Proteins

Human DKK1 Protein, mFc Tag

SKU:  PME101245     Target:  DKK1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101244 RHOC Fig.1 SDS PAGE 1

ECD Proteins

Human RHOC(1-189) Protein, hFc Tag

SKU:  PME101244     Target:  RhoC

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101243 RHOB Fig.1 SDS PAGE 1

ECD Proteins

Human RHOB Protein, hFc Tag

SKU:  PME101243     Target:  RHOB

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101241 CXADR Fig.1 SDS PAGE 1

ECD Proteins

Human CXADR Protein, His Tag

SKU:  PME101241     Target:  CXADR

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101240 APLP2 Fig.1 SDS PAGE 1

ECD Proteins

Human APLP2 Protein, His Tag

SKU:  PME101240     Target:  APLP2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101239 DKK1 Fig.1 SDS PAGE 1

ECD Proteins

Human DKK1 Protein, His Tag

SKU:  PME101239     Target:  DKK1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00