DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME101175 Target: PROKR1
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101174 Target: MSMP
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101168 Target: IL8
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101167 Target: VPS4
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101172 Target: PDGFD
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101166 Target: PDGFD
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101165 Target: IL17F
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101164 Target: NRP2
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101163 Target: LRG1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101162 Target: AGTR1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101160 Target: IL10
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101159 Target: FGL1
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME101157 Target: PTTG1IP
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101156 Target: IL9
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101155 Target: IL9
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101154 Target: ULBP2
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME101153 Target: PRTN3
Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00
ECD Proteins
SKU: PME30072 Target: IL-15RA and IL-15
Price: 50 μg $360.00
