Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-PME101237 TGFA Fig.1 SDS PAGE 1

ECD Proteins

Human TGFA Protein, hFc Tag

SKU:  PME101057     Target:  TGFA

Price: 10μg $70.00; 50μg $256.00 ; 100μg $385.00

sp-PME101236 CCL19 Fig.1 SDS PAGE 1

ECD Proteins

Human CCL19 Protein, hFc Tag

SKU:  PME101236     Target:  CCL19

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101235 BTC Fig.1 SDS PAGE 1

ECD Proteins

Human BTC Protein, hFc Tag

SKU:  PME101235     Target:  BTC

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101234 ACVRL1 Fig.1 SDS PAGE 1

ECD Proteins

Human ACVRL1 Protein, hFc Tag

SKU:  PME101234     Target:  ACVRL1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101233 ACVR1C Fig.1 SDS PAGE 1

ECD Proteins

Human ACVR1C Protein, hFc Tag

SKU:  PME101233     Target:  ACVR1C

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101232 LYPD3 Fig.1 SDS PAGE 1

ECD Proteins

Human LYPD3(31-325) Protein, His Tag

SKU:  PME101232     Target:  LYPD3

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101231 LYPD3 Fig.1 SDS PAGE 1

ECD Proteins

Human LYPD3(31-286) Protein, His Tag

SKU:  PME101231     Target:  LYPD3

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101230 CD14 Fig.1 SDS PAGE 1

ECD Proteins

Human CD14(20-352) Protein, His Tag

SKU:  PME101230     Target:  CD14

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101229 CD14 Fig.1 SDS PAGE 1

ECD Proteins

Human CD14(20-344) Protein, His Tag

SKU:  PME101229     Target:  CD14

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101228 GPR56 Fig.1 SDS PAGE 1

ECD Proteins

Human GPR56 Protein, His Tag

SKU:  PME101228     Target:  GPR56

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101227 ACHE Fig.1 SDS PAGE 1

ECD Proteins

Human ACHE Protein, His Tag

SKU:  PME101227     Target:  ACHE

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-PME101226 ANGPTL7 Fig.1 SDS PAGE 1

ECD Proteins

Human ANGPTL7 Protein, His Tag

SKU:  PME101226     Target:  ANGPTL7

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101225 AZU1 Fig.1 SDS PAGE 1

ECD Proteins

Human AZU1 Protein, His Tag

SKU:  PME101225     Target:  AZU1

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101224 SEZ6L2 Fig.1 SDS PAGE 1

ECD Proteins

Human SEZ6L2 Protein, His Tag

SKU:  PME101224     Target:  SEZ6L2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-PME101207 CLDN6 Fig.1 SDS PAGE 1

ECD Proteins

Human CLDN6(138-160) Protein, hFc Tag

SKU:  PME101207     Target:  CLDN6

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-PME101206 CLDN6 Fig.1 SDS PAGE 1

ECD Proteins

Human CLDN6(29-81) Protein, hFc Tag

SKU:  PME101206     Target:  CLDN6

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

PME101246 human CXADR hFc recombinant protein

ECD Proteins

Human CXADR Protein, hFc Tag

SKU:  PME101246     Target:  CXADR

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101242 alpp sp1

ECD Proteins

Human ALPP Protein, His Tag

SKU:  PME101242     Target:  ALPP

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-pme101238 il23a il12b sp1

ECD Proteins

Human IL23A and IL12B Heterodimer Protein, hFc Tag and His Tag

SKU:  PME101238     Target:  IL23A and IL12B

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101223 siglec5 sp1

ECD Proteins

Human SIGLEC5 Protein, His Tag

SKU:  PME101223     Target:  SIGLEC5

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101222 sirpg sp1

ECD Proteins

Human SIRPG Protein, His Tag

SKU:  PME101222     Target:  SIRPG

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101221 spa17 sp1

ECD Proteins

Human SPA17 Protein, His Tag

SKU:  PME101221     Target:  SPA17

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101220 plxdc2 sp1

ECD Proteins

Human PLXDC2 Protein, His Tag

SKU:  PME101220     Target:  PLXDC2

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101219 tff1 sp1

ECD Proteins

Human TFF1 Protein, hFc Tag

SKU:  PME101219     Target:  TFF1

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101218 s100a4 sp1

ECD Proteins

Human S100A4 Protein, hFc Tag

SKU:  PME101218     Target:  S100A4

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-pme101217 bmpr1a sp1

ECD Proteins

Human BMPR1A Protein, hFc Tag

SKU:  PME101217     Target:  BMPR1A

Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00

sp-pme101216 bmp2 sp1

ECD Proteins

Human BMP2 Protein, hFc Tag

SKU:  PME101216     Target:  BMP2

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101215 selenop sp1

ECD Proteins

Human Selenop Protein, Flag Tag

SKU:  PME101215     Target:  Selenop

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101214 bace1 sp1

ECD Proteins

Human BACE1 Protein, His Tag

SKU:  PME101214     Target:  BACE1

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101213 bche sp1

ECD Proteins

Human BCHE Protein, His Tag

SKU:  PME101213     Target:  BCHE

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme101212 angpt2 sp1

ECD Proteins

Human ANGPT2(275-496) Protein, His Tag

SKU:  PME101212     Target:  ANGPT2

Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00

sp-pme101211 angpt2 sp1

ECD Proteins

Human ANGPT2(19-496) Protein, His Tag

SKU:  PME101211     Target:  ANGPT2

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00