DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME101209 Target: BTN2A1
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101208 Target: SLAMF8
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101204 Target: CADM1
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101203 Target: CLEC1B
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101202 Target: CD300LG
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101201 Target: CD55
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101200 Target: CD163
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101199 Target: LDLR
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101198 Target: SERPINF2
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101197 Target: SEMA4B
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101196 Target: ANPRB
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101195 Target: VSTM5
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101194 Target: SEZ6
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101192 Target: TIMP1
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101191 Target: IL23A
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101190 Target: HCRTR1
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101189 Target: CLDN6
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101188 Target: CLDN6
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101177 Target: PODXL2
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101171 Target: CDH11
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101170 Target: CDH11
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101169 Target: CDH10
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME100082 Target: TNFRSF1B
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101193 Target: LRP6
Price: 10μg $91.00; 50μg $328.00 ; 100μg $488.00
ECD Proteins
SKU: PME101187 Target: LGALS3BP
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101186 Target: BTK
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101184 Target: CLDN4
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
ECD Proteins
SKU: PME101183 Target: CLDN4
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME101182 Target: CLDN3
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101181 Target: CLDN3
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101180 Target: FZD7
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME101178 Target: POSTN
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00