DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME100854 Target: APRIL
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
ECD Proteins
SKU: PME100853 Target: TNFRSF11A
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100852 Target: NCR1
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100623 Target: CHI3L1
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100604 Target: CLU
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100848 Target: CD99
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100321 Target: KLRG1
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100844 Target: KIR2DL2
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100841 Target: IL8
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100840 Target: IL7RA
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100838 Target: IL1B
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100836 Target: LRRC32
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100835 Target: CXCR5
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100834 Target: CXCR4
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100833 Target: CXCR3
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
ECD Proteins
SKU: PME100832 Target: CLEC2D
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100831 Target: CEACAM1
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100830 Target: C5AR1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100829 Target: CD73
Price: 10μg $137.00 ; 50μg $513.00 ; 100 μg $752.00
ECD Proteins
SKU: PME100828 Target: CD3E
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100827 Target: CD200R1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100826 Target: CCR9
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100825 Target: CCR7
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100824 Target: CCR4
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100822 Target: CEACAM6
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100821 Target: MST1R
Price: 10μg $137.00 ; 50μg $513.00 ; 100 μg $752.00
ECD Proteins
SKU: PME100820 Target: CXCR1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100818 Target: CD39
Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00
ECD Proteins
SKU: PME100813 Target: CD21
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100812 Target: CD147
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100810 Target: ANPEP
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100809 Target: IL4RA
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00