Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

pages-416107bc534d939 1

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

pages-cvsdvdfffffb 1

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme100076 tnfa sp1

ECD Proteins

Human TNFa Protein, His Tag

SKU:  PME100076     Target:  TNFA

Price: 10μg $91.00; 50μg $348.00 ; 100 μg $522.00

sp-pme100074 il2rb sp1

ECD Proteins

Human IL2RB Protein, His Tag

SKU:  PME100074     Target:  IL2RB

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100073 ace2 sp1

ECD Proteins

Human ACE2 Protein, hFc Tag

SKU:  PME100073     Target:  ACE2

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100071 cecam5 sp1

ECD Proteins

Human CEACAM5 Protein, His Tag

SKU:  PME100071     Target:  CEACAM5

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100035 bcma sp1

ECD Proteins

Human BCMA Protein, mFc Tag

SKU:  PME100035     Target:  BCMA

Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00

sp-pme100470 cd5 sp1

ECD Proteins

Human CD5 Protein, His Tag

SKU:  PME100470     Target:  CD5

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100466 cd200 sp1

ECD Proteins

Human CD200 Protein, His Tag

SKU:  PME100466     Target:  CD200

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100070 axl sp1

ECD Proteins

Human AXL Protein, His Tag

SKU:  PME100070     Target:  AXL

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100069 fcgr3a sp1

ECD Proteins

Human FCGR3A Protein (F176V), His Tag

SKU:  PME100069     Target:  FCGR3A

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100061 cd52 sp1

ECD Proteins

Human CD52 Protein, mFc Tag

SKU:  PME100061     Target:  CD52

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100042 cd70 sp1

ECD Proteins

Human CD70 Protein, mFc-His Tag

SKU:  PME100042     Target:  CD70

Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00

sp-pme100039 cd33 sp1

ECD Proteins

Human CD33(18-259) Protein, hFc-His Tag

SKU:  PME100039     Target:  CD33

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100059 ntba sp1

ECD Proteins

Human NTB-A Protein, mFc-His Tag

SKU:  PME100059     Target:  NTB-A

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100469 cd34 sp1

ECD Proteins

Human CD34 Protein, His Tag

SKU:  PME100469     Target:  CD34

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100468 il17ra sp1

ECD Proteins

Human IL17RA Protein, His Tag

SKU:  PME100468     Target:  IL17RA

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100465 tnfrsf10b sp1

ECD Proteins

Human TNFRSF10B Protein, mFc Tag

SKU:  PME100465     Target:  TNFRSF10B

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100067 csf1r sp1

ECD Proteins

Human CSF1R Protein, His Tag

SKU:  PME100067     Target:  CSF1R

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100048 btla sp1

ECD Proteins

Human BTLA Protein, mFc-His Tag

SKU:  PME100048     Target:  BTLA

Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00

sp-pme100068 epcam sp1

ECD Proteins

Human EPCAM Protein, His Tag

SKU:  PME100068     Target:  EPCAM

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100050 dnam 1 sp1

ECD Proteins

Human DNAM-1 Protein, mFc-His Tag

SKU:  PME100050     Target:  DNAM1

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100045 epha3 sp1

ECD Proteins

Human EPHA3 Protein, mFc-His Tag

SKU:  PME100045     Target:  EPHA3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100464 cd7 sp1

ECD Proteins

Human CD7 Protein, mFc Tag

SKU:  PME100464     Target:  CD7

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100463 tweakr sp1

ECD Proteins

Human TweakR Protein, mFc Tag

SKU:  PME100463     Target:  TweakR

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100462 pd1 sp1

ECD Proteins

Human PD-1 Protein, hFc-His tag

SKU:  PME100462     Target:  PD-1

Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00

sp-pme100461 pd 1 sp1

ECD Proteins

Human PD-1 Protein, His tag

SKU:  PME100461     Target:  PD-1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100460 s rbd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S protein RBD, mFc-His Tag

SKU:  PME100460     Target:  S protein RBD

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100459 nucleocapsid sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) Nucleocapsid, N-His Tag

SKU:  PME100459     Target:  Nucleocapsid

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme100034 b7 2 sp1

ECD Proteins

Human B7-2 Protein, mFc-His Tag

SKU:  PME100034     Target:  B7-2

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100033 flt3lg sp1 1

ECD Proteins

Human FLT3 Ligand Protein, mFc-His Tag

SKU:  PME100033     Target:  FLT3LG

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00

sp-pme100032 il6 sp1 1

ECD Proteins

Human IL6 Protein, mFc-His Tag

SKU:  PME100032     Target:  IL6

Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00

sp-pme100031 msln296 sp1 1

ECD Proteins

Human Mesothelin (296-580) Protein, mFc-His Tag

SKU:  PME100031     Target:  Mesothelin

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100030 tim3 sp1 1

ECD Proteins

Human TIM3 Protein, mFc-His Tag

SKU:  PME100030     Target:  TIM3

Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00