DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME100808 Target: ITGAM
Price: 10μg $100.00 ; 50μg $358.00 ; 100μg $528.00
ECD Proteins
SKU: PME100806 Target: SSTR2
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100803 Target: GPA33
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100802 Target: CDH3
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100801 Target: CDH17
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100192 Target: CD40 Ligand
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100103 Target: TGFBR1
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100102 Target: CD46
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100099 Target: EGFR
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100098 Target: IL2RA
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100097 Target: ROR2
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100096 Target: CLEC12A
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100095 Target: Her2
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100094 Target: TACI
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100038 Target: CD19
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100506 Target: TIGIT
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100505 Target: TIGIT
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100107 Target: TIGIT
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100054 Target: 4-1BB Ligand
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME-M100035 Target: STAB1
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100041 Target: CD30 Ligand
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100800 Target: CD3D
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $450.00
ECD Proteins
SKU: PME100504 Target: Nucleocapsid
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100092 Target: SIGLEC10
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100091 Target: CD37
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100088 Target: HER3
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100085 Target: IL5
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100503 Target: BAFF-R
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100471 Target: SELPLG
Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100044 Target: BAFF-R
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100043 Target: BAFF
Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME100502 Target: 4-1BB
Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00