Biosimilar reference antibodies

To develop a superior biologic drug, it is important to synthesize a benchmark reference antibody. The reference antibody can greatly facilitate the downstream development. It can help identify critical cell lines, reagents, performance characteristics, etc.

DIMA Biotechnology LTD utilizes HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, target binding verification, etc.

Product targets:

CD47	IL6	SARS-CoV	CD30	CD20	TNFRSF10B
CS1	TIM3	CD138	CD40	TIGIT	TweakR
CD123	PDL1	CD33	MSLN	TIGIT	CD22
CD38	B7-H3	CD27	CTLA4	BCMA	TIGIT
CD70	SARS-CoV-2	EPHA3	Trop2	EGFR	AXL
PD-1-1	ICOS	CEACAM5	4-1BB	IL17RA	NKG2D
CA9	IL6R	CD40L	IL2RA	BAFF	BAFFR
CD37

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• Strict Quality Control
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Active protein detection

Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human PD1, mFc-His tagged protein (PME100025) can bind Anti-PD-1 Neutralizing antibody in a linear range of 0.24-6.49 ng/ml.

Comparison of flow functional detection

Figure 2. HEK293 cell line transfected with irrelevant protein (B) and human PD1(A) were surface stained with anti-PD1 neutralizing antibody 1μg/ml (pembrolizumab) followed by Alexa 488-conjugated anti-human IgG secondary antibody.