Author Archives: 瑶 翟

New Product Launch | DT3C Protein: A Powerful Tool for Validating Antibody Internalization

Are you developing antibody-drug conjugates (ADCs)? Are you seeking a reliable and standardized method to evaluate antibody internalization? We are proud to introduce the DT3C Protein (Cat. No. AME100004) — a novel recombinant fusion protein designed to simulate ADC mechanisms and provide a fast, universal, and functional solution for antibody internalization assessment. 1. What is […]

News 2025-06-13

FLT3 | A Key Therapeutic Target in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a complex and highly heterogeneous hematologic malignancy closely associated with various cytogenetic and chromosomal abnormalities. Among them, mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are one of the most common genetic alterations. Studies have shown that approximately 25% of AML patients carry FLT3 internal tandem duplication mutations (FLT3-ITD), while about […]

Blog 2025-05-20

NPY Receptor Family: “New Targets” and “Old Challenges” in Disease Treatment

In the drug development efforts targeting complex diseases such as neuropsychiatric disorders, metabolic dysregulation, and cancer, the neuropeptide Y (NPY) receptor family is garnering increasing attention from researchers and pharmaceutical companies alike. As a typical subfamily of G protein-coupled receptors (GPCRs), NPY receptors not only regulate a variety of physiological processes but also play critical […]

Blog 2025-04-28

Unlocking a New Era in Membrane Protein Research: Nanodiscs Empower AI Drug Discovery and Cryo-EM Analysis

In recent years, the rapid development of AI-driven drug discovery (AI-based drug discovery) and Cryo-EM (cryo-electron microscopy) has gradually unveiled the mysteries of many previously considered “undruggable” protein targets. Among them, membrane proteins, which are crucial targets for drug development, are now seeing unprecedented breakthroughs under the dual influence of AI and Cryo-EM technologies. However, membrane protein […]

Blog 2025-04-11

Dual-Function Reagent for ADC Screening: Evaluating Internalization and Cytotoxicity in One Step

In recent years, Antibody-Drug Conjugates (ADCs) have gained widespread attention as a key strategy in targeted cancer therapies. The effectiveness of ADCs relies on the specific targeting of the antibody, efficient internalization, and the release of the payload toxin. Therefore, evaluating both the internalization efficiency and cytotoxicity introduced by antibody-payload complex is crucial in ADC […]

Blog 2025-04-01

China’s Growing Impact on ADC Development at AACR 2025

The 2025 American Association for Cancer Research (AACR) Annual Meeting is set to take place in Chicago, USA, from April 25 to 30. The recently released conference abstracts highlight the strong presence of Chinese biopharmaceutical companies in the field of antibody-drug conjugates (ADCs). At this year’s conference, Chinese pharmaceutical companies dominate the ADC field, presenting […]

Blog 2025-04-01

HER2 | A Key Target in Solid Tumor Therapy

On November 20, 2024, Jazz Pharmaceuticals announced that the bispecific antibody Zanidatamab had received accelerated approval from the FDA for the treatment of adult patients with previously treated, unresectable, or metastatic HER2-positive (HER2+, defined as IHC 3+) biliary tract cancer (BTC). Zanidatamab is the first approved HER2-targeting bispecific antibody with dual epitope specificity. On December […]

Blog , 2025-02-28

Exciting Launch: The New Anti-(G4S)4 Antibody is Here!

1. About (G4S)n Linkers   The (G4S)n linker refers to a flexible linker composed of one or more repeating units of G4S (Gly-Gly-Gly-Gly-Ser). Due to its moderate length and flexibility, this linker is widely used in molecular designs requiring the connection of two proteins or peptides. 1.1 Structure Amino Acid Sequence: (Gly-Gly-Gly-Gly-Ser)n Repeating Modules: Composed of […]

Blog 2025-01-14

Optimizing GPCR Expression and Purification: Enhancing Synthetic Nanodisc Technology with Multiple Tag Strategies

1. About Synthetic Nanodisc The lipid composition of traditional membrane scaffold protein (MSP) nanodiscs often differs from that of natural cell membranes, which can lead to deviations in membrane protein properties compared to their native environment. To address this limitation, DIMA has developed the Synthetic Nanodisc platform. This innovative technology enables the direct preparation of […]

Blog 2024-12-26

PSMA: A Key Target for Radiotherapy and Diagnosis in Prostate Cancer

Prostate-specific membrane antigen (PSMA) is a pivotal molecular target in the treatment and diagnosis of prostate cancer (PCa). Over the past two decades, extensive research has illuminated its unique molecular characteristics, paving the way for advanced diagnostic and therapeutic approaches. PSMA-targeted imaging techniques, particularly positron emission tomography (PET) radiotracers, have demonstrated exceptional sensitivity in detecting […]

Blog 2024-12-13