G protein-coupled receptors (GPCRs) are among the most important targets in modern drug discovery, yet they remain one of the most challenging protein classes for antibody development. The difficulty lies in producing stable, native like GPCR antigens that preserve functional conformation.
At DIMA Biotechnology, we have developed an integrated platform that combines proprietary full-length Nanodisc GPCR proteins with single B-cell cloning technology to enable efficient discovery of high-quality monoclonal antibodies. Our Nanodisc-based antigens maintain native structure and biological activity, significantly improving antibody specificity, affinity, and functional relevance.
This approach enables rapid and reliable generation of monoclonal antibodies against even the most difficult GPCR targets, supporting applications in research, diagnostics, and therapeutic development.
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Learn how DIMA’s Nanodisc-based GPCR proteins enable high-success antibody discovery by overcoming key antigen challenges and accelerating development.
Highlights
- Nanodisc GPCR antigens for improved antibody quality
- Single B-cell cloning for rapid discovery
- Higher success rates and faster timelines
Technology Platforms Behind the Discovery
Nanodisc GPCR protein platforms
Single B-cell cloning technology
Products & Services
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