Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101161 e8l sp1

ECD Proteins

Monkeypox virus E8L Protein, His Tag

SKU:  PME101161     Target:  E8L

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101152 a35r sp1

ECD Proteins

Monkeypox virus A35R Protein, His Tag

SKU:  PME101152     Target:  A35R

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101151 a29l sp1

ECD Proteins

Monkeypox virus A29L Protein, His Tag

SKU:  PME101151     Target:  A29L

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101034 xage1a sp1

ECD Proteins

Human XAGE1A Protein, hFc Tag

SKU:  PME101034     Target:  XAGE1A

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-PME101158 NLRP3 Fig.1 SDS PAGE 1

ECD Proteins

Human NLRP3 Protein, Flag Tag

SKU:  PME101158     Target:  NLRP3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100076 asgr1 sp1

ECD Proteins

Mouse ASGR1 Protein, His Tag

SKU:  PME-M100076     Target:  ASGR1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100075 bmp6 sp1

ECD Proteins

Mouse BMP6 Protein, His Tag

SKU:  PME-M100075     Target:  BMP6

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme c100011 btn3a1 sp1

ECD Proteins

Cynomolgus BTN3A1 Protein, His Tag

SKU:  PME-C100011     Target:  BTN3A1

Price:10μg $120.00; 50μg $380.00; 100μg $570.00

sp-pme101150 ceacam8 sp1

ECD Proteins

Human CEACAM8 Protein, His Tag

SKU:  PME101150     Target:  CEACAM8

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101149 fgfr3 sp1

ECD Proteins

Human FGFR3 Protein, His Tag

SKU:  PME101149     Target:  FGFR3

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101148 pcdh18 sp1

ECD Proteins

Human PCDH18 Protein, His Tag

SKU:  PME101148     Target:  PCDH18

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101147 dlk1 sp1

ECD Proteins

Human DLK1 Protein, His Tag

SKU:  PME101147     Target:  DLK1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101145 bcam sp1

ECD Proteins

Human BCAM Protein, His Tag

SKU:  PME101145     Target:  BCAM

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101144 cd106 sp1

ECD Proteins

Human CD106 Protein, hFc Tag

SKU:  PME101144     Target:  CD106

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101143 lamp3 sp1

ECD Proteins

Human LAMP3 Protein, His Tag

SKU:  PME101143     Target:  LAMP3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101142 btn3a2 sp1

ECD Proteins

Human BTN3A2 Protein, His Tag

SKU:  PME101142     Target:  BTN3A2

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101141 asgr1 sp1

ECD Proteins

Human ASGR1 Protein, His Tag

SKU:  PME101141     Target:  ASGR1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101140 furin sp1

ECD Proteins

Human FURIN Protein, His Tag

SKU:  PME101140     Target:  FURIN

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

fc-PME100559P PE GPRC5D mFc FLOW Fig.1

ECD Proteins

PE-conjugated Human GPRC5D Protein, mFc Tag

SKU:  PME100559P     Target:  GPRC5D

Price: 25test $340.00

sp-pme101125 igfbp2 sp1

ECD Proteins

Human IGFBP2 Protein, His Tag

SKU:  PME101125     Target:  IGFBP2

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101139 btn3a3 sp1

ECD Proteins

Human BTN3A3 Protein, His Tag

SKU:  PME101139     Target:  BTN3A3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101138 cd94 sp1

ECD Proteins

Human CD94 Protein, hFc Tag

SKU:  PME101138     Target:  CD94

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101137 tspan8 sp1

ECD Proteins

Human TSPAN8 Protein, hFc Tag

SKU:  PME101137     Target:  TSPAN8

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101136 pyy sp1

ECD Proteins

Human PYY Protein, hFc Tag

SKU:  PME101136     Target:  PYY

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101135 retn sp1

ECD Proteins

Human RETN Protein, hFc Tag

SKU:  PME101135     Target:  RETN

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101134 klk3 sp1

ECD Proteins

Human KLK3 Protein, His Tag

SKU:  PME101134     Target:  KLK3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101133 il12b sp1

ECD Proteins

Human IL12B Protein, His Tag

SKU:  PME101133     Target:  IL12B

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101111 cdh6 sp1

ECD Proteins

Human CDH6 Protein, His Tag

SKU:  PME101111     Target:  CDH6

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101132 areg sp1

ECD Proteins

Human AREG Protein, hFc Tag

SKU:  PME101132     Target:  AREG

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101131 sema4d sp1

ECD Proteins

Human SEMA4D Protein, His Tag

SKU:  PME101131     Target:  SEMA4D

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101129 cd59 sp1

ECD Proteins

Human CD59 Protein, hFc Tag

SKU:  PME101129     Target:  CD59

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101128 il13 sp1

ECD Proteins

Human IL13(35-146) Protein, hFc Tag

SKU:  PME101128     Target:  IL13

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00