DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Hot Duggable Targets
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
ECD Proteins
ECD Proteins
SKU: PME-M100051 Target: CSF1R
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100050 Target: SIRPa
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100049 Target: CD48
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100048 Target: TIM3
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100047 Target: B7-H2
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100046 Target: B7-2
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100045 Target: PSCA
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100044 Target: B7-1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100043 Target: OX40
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100042 Target: CD40
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME-M100041 Target: DNAM1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100040 Target: Mesothelin
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100039 Target: QSOX1
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME-M100038 Target: ADAM28
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100773 Target: IFNAR1
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100772 Target: S protein RBD
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100771 Target: ADAMTS1
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100770 Target: TPSAB1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100769 Target: FGF21
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100768 Target: B7-H7
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100767 Target: CD72
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100766 Target: Trop2
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100765 Target: TIMP4
Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00
SKU: PME100764 Target: ITGAX and ITGB2
Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00
ECD Proteins
SKU: PME100763 Target: CLDN5
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100762 Target: RNF43
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100761 Target: RNF43
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100760 Target: ANXA1
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME100759 Target: LIV-1
Price: 10μg $137.00 ; 50μg $513.00 ; 100 μg $752.00
ECD Proteins
SKU: PME100753 Target: ADAM15
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00
ECD Proteins
SKU: PME100661 Target: EDA
Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00
ECD Proteins
SKU: PME-M100037 Target: NCL
Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00