Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme m100060 ceacam5 sp1

ECD Proteins

Mouse CEACAM5 Protein, His Tag

SKU:  PME-M100060     Target:  CEACAM5

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100798 slpi sp1

ECD Proteins

Human SLPI Protein, hFc Tag

SKU:  PME100798     Target:  SLPI

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100797 trem1 sp1

ECD Proteins

Human TREM1 Protein, hFc Tag

SKU:  PME100797     Target:  TREM1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100796 mfap5 sp1

ECD Proteins

Human MFAP5 Protein, hFc Tag

SKU:  PME100796     Target:  MFAP5

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100795 lamp5 sp1

ECD Proteins

Human LAMP5 Protein, hFc Tag

SKU:  PME100795     Target:  LAMP5

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100794 nts sp1

ECD Proteins

Human NTS Protein, hFc Tag

SKU:  PME100794     Target:  NTS

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100793 ltbr sp1

ECD Proteins

Human LTBR Protein, hFc Tag

SKU:  PME100793     Target:  LTBR

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100791 plaur sp1

ECD Proteins

Human PLAUR Protein, His Tag

SKU:  PME100791     Target:  PLAUR

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100790 nrp1 sp1

ECD Proteins

Human NRP1 Protein, His Tag

SKU:  PME100790     Target:  NRP1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100789 pglyrp1 sp1

ECD Proteins

Human PGLYRP1 Protein, His Tag

SKU:  PME100789     Target:  PGLYRP1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100788 il18rap sp1

ECD Proteins

Human IL18RAP Protein, His Tag

SKU:  PME100788     Target:  IL18RAP

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100786 ca12 sp1

ECD Proteins

Human CA12 Protein, hFc Tag

SKU:  PME100786     Target:  CA12

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100785 ifna1 sp1

ECD Proteins

Human IFNA1 Protein, hFc Tag

SKU:  PME100785     Target:  IFNA1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100784 mcemp1 sp1

ECD Proteins

Human MCEMP1 Protein, hFc Tag

SKU:  PME100784     Target:  MCEMP1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100783 agr2 sp1

ECD Proteins

Human AGR2 Protein, hFc Tag

SKU:  PME100783     Target:  AGR2

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100782 cldn2 sp1

ECD Proteins

Human CLDN2 Protein, hFc Tag

SKU:  PME100782     Target:  CLDN2

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100781 cd19 sp1

ECD Proteins

Human CD19 Protein, mFc Tag

SKU:  PME100781     Target:  CD19

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme100780 rspo1 sp1

ECD Proteins

Human RSPO1(21-146) Protein, hFc Tag

SKU:  PME100780     Target:  RSPO1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100779 rspo1 sp1

ECD Proteins

Human RSPO1(21-263) Protein, His Tag

SKU:  PME100779     Target:  RSPO1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100778 qsox1 sp1

ECD Proteins

Human QSOX1 Protein, His Tag

SKU:  PME100778     Target:  QSOX1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100777 tgfbr1 sp1

ECD Proteins

Human TGFBR1 Protein, hFc Tag

SKU:  PME100777     Target:  TGFBR1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100776 cd52 sp1

ECD Proteins

Human CD52 Protein, hFc Tag

SKU:  PME100776     Target:  CD52

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100775 tfrc sp1

ECD Proteins

Human TFRC Protein, His Tag

SKU:  PME100775     Target:  TFRC

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100774 cd106 sp1

ECD Proteins

Human CD106 Protein, His Tag

SKU:  PME100774     Target:  CD106

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100059 tweakr sp1

ECD Proteins

Mouse TweakR Protein, hFc Tag

SKU:  PME-M100059     Target:  TweakR

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100058 slamf1 sp1

ECD Proteins

Mouse SLAMF1 Protein, hFc Tag

SKU:  PME-M100058     Target:  SLAMF1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100057 tnfrsf10b sp1

ECD Proteins

Mouse TNFRSF10B Protein, hFc Tag

SKU:  PME-M100057     Target:  TNFRSF10B

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100056 slamf5 sp1

ECD Proteins

Mouse SLAMF5 Protein, hFc Tag

SKU:  PME-M100056     Target:  SLAMF5

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100055 cb1 sp1

ECD Proteins

Mouse CB1 Protein, hFc Tag

SKU:  PME-M100055     Target:  CB1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100054 cd200 sp1

ECD Proteins

Mouse CD200 Protein, hFc Tag

SKU:  PME-M100054     Target:  CD200

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100053 tigit sp1

ECD Proteins

Mouse TIGIT Protein, hFc Tag

SKU:  PME-M100053     Target:  TIGIT

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100052 il17ra sp1

ECD Proteins

Mouse IL17RA Protein, His Tag

SKU:  PME-M100052     Target:  IL17RA

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00