Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

pages-416107bc534d939 1

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

pages-cvsdvdfffffb 1

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme101127 ppt1 sp1

ECD Proteins

Human PPT1 Protein, His Tag

SKU:  PME101127     Target:  PPT1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101126 il18bp sp1

ECD Proteins

Human IL18BP Protein, hFc Tag

SKU:  PME101126     Target:  IL18BP

Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00

sp-pme101124 npr1 sp1

ECD Proteins

Human NPR1 Protein, hFc Tag

SKU:  PME101124     Target:  NPR1

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101123 bmp6 sp1

ECD Proteins

Human BMP6 Protein, His Tag

SKU:  PME101123     Target:  BMP6

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101120 bst2 sp1

ECD Proteins

Human BST2 Protein, hFc Tag

SKU:  PME101120     Target:  BST2

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101119 fam3d sp1

ECD Proteins

Human FAM3D Protein, hFc Tag

SKU:  PME101119     Target:  FAM3D

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101118 f2rl1 sp1

ECD Proteins

Human F2RL1 Protein, hFc Tag

SKU:  PME101118     Target:  F2RL1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101117 amigo2 sp1

ECD Proteins

Human AMIGO2 Protein, His Tag

SKU:  PME101117     Target:  AMIGO2

Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00

sp-pme101116 scg3 sp1

ECD Proteins

Human SCG3 Protein, His Tag

SKU:  PME101116     Target:  SCG3

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101115 osmr sp1

ECD Proteins

Human OSMR Protein, His Tag

SKU:  PME101115     Target:  OSMR

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101114 hsd17b13 sp1

ECD Proteins

Human HSD17B13 Protein, Flag Tag

SKU:  PME101114     Target:  HSD17B13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101112 ccr4 sp1

ECD Proteins

Human CCR4(1-39) Protein, mFc Tag

SKU:  PME101112     Target:  CCR4

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101110 gpr87 sp1

ECD Proteins

Human GPR87 Protein, mFc Tag

SKU:  PME101110     Target:  GPR87

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101109 ccr2 sp1

ECD Proteins

Human CCR2 Protein, mFc Tag

SKU:  PME101109     Target:  CCR2

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101108 gprc5c sp1

ECD Proteins

Human GPRC5C Protein, mFc Tag

SKU:  PME101108     Target:  GPRC5C

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101107 gprc5b sp1

ECD Proteins

Human GPRC5B Protein, mFc Tag

SKU:  PME101107     Target:  GPRC5B

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme101106 gprc5a sp1

ECD Proteins

Human GPRC5A Protein, mFc Tag

SKU:  PME101106     Target:  GPRC5A

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme101105 ccr6 sp1

ECD Proteins

Human CCR6 Protein, mFc Tag

SKU:  PME101105     Target:  CCR6

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme100799 cxcr3 sp1

ECD Proteins

Human CXCR3 Protein, mFc Tag

SKU:  PME100799     Target:  CXCR3

Price: 10μg $85.00; 50μg $310.00 ; 100 μg $460.00

sp-pme101146 s protein rbd sp1

ECD Proteins

SARS-CoV-2 (Omicron BA.5) S protein RBD, hFc Tag

SKU:  PME101146     Target:  S protein RBD

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100072 baff sp1

ECD Proteins

Mouse BAFF Protein, hFc Tag

SKU:  PME-M100072     Target:  BAFF

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100071 4 1bb ligand sp1

ECD Proteins

Mouse 4-1BB Ligand Protein, hFc Tag

SKU:  PME-M100071     Target:  4-1BB Ligand

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100070 nkg2d sp1

ECD Proteins

Mouse NKG2D Protein, hFc Tag

SKU:  PME-M100070     Target:  NKG2D

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100069 ror1 sp1

ECD Proteins

Mouse ROR1 Protein, His Tag

SKU:  PME-M100069     Target:  ROR1

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100068 cd40 ligand sp1

ECD Proteins

Mouse CD40 Ligand Protein, hFc Tag

SKU:  PME-M100068     Target:  CD40 Ligand

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100067 ox40 ligand sp1

ECD Proteins

Mouse OX40 Ligand Protein, hFc Tag

SKU:  PME-M100067     Target:  OX40 Ligand

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100066 gitr ligand sp1

ECD Proteins

Mouse GITR Ligand Protein, hFc Tag

SKU:  PME-M100066     Target:  GITR Ligand

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100065 taci sp1

ECD Proteins

Mouse TACI Protein, hFc Tag

SKU:  PME-M100065     Target:  TACI

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100064 cd34 sp1

ECD Proteins

Mouse CD34 Protein, hFc Tag

SKU:  PME-M100064     Target:  CD34

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100063 il2ra sp1

ECD Proteins

Mouse IL2RA Protein, hFc Tag

SKU:  PME-M100063     Target:  IL2RA

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100062 egfr sp1

ECD Proteins

Mouse EGFR Protein, His Tag

SKU:  PME-M100062     Target:  EGFR

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00

sp-pme m100061 cd22 sp1

ECD Proteins

Mouse CD22 Protein, His Tag

SKU:  PME-M100061     Target:  CD22

Price: 10μg $103.00 ; 50μg $388.00 ; 100 μg $568.00