Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme c100005 ighe sp1

ECD Proteins

Cynomolgus IgHE Protein, His Tag

SKU:  PME-C100005     Target:  IgHE

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme100709 ddr1 sp1

ECD Proteins

Human DDR1 Protein, His Tag

SKU:  PME100709     Target:  DDR1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100704 gpr75 sp1

ECD Proteins

Human GPR75 Protein, hFc Tag

SKU:  PME100704     Target:  GPR75

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100703 b4galt1 sp1

ECD Proteins

Human B4GALT1 Protein, hFc Tag

SKU:  PME100703     Target:  B4GALT1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100699 mmp13 sp1

ECD Proteins

Human MMP13 Protein, hFc Tag

SKU:  PME100699     Target:  MMP13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100698 mmp13 sp1

ECD Proteins

Human MMP13 Protein, His Tag

SKU:  PME100698     Target:  MMP13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100696 igfbp7 sp1

ECD Proteins

Human IGFBP7 Protein, hFc Tag

SKU:  PME100696     Target:  IGFBP7

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme102006 mbp sp1

ECD Proteins

Human MBP Protein, hFc Tag

SKU:  PME102006     Target:  MBP

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme c100004 ncl sp1

ECD Proteins

Rhesus macaque NCL Protein, His Tag

SKU:  PME-C100004     Target:  NCL

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme m100027 mfge8 sp1

ECD Proteins

Mouse MFGE8 Protein, His Tag

SKU:  PME-M100027     Target:  MFGE8

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100814 igf 1r sp1

ECD Proteins

Human IGF-1R Protein, His Tag

SKU:  PME100814     Target:  IGF-1R

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100693 cd33 sp1

ECD Proteins

Human CD33(140-259) Protein, hFc Tag

SKU:  PME100693     Target:  CD33

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100692 cdh1 sp1

ECD Proteins

Human CDH1 Protein, mFc Tag

SKU:  PME100692     Target:  CDH1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100694 pglyrp1 sp1

ECD Proteins

Human PGLYRP1 Protein, hFc Tag

SKU:  PME100694     Target:  PGLYRP1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100026 vwf sp1

ECD Proteins

Mouse VWF (23-2813) Protein, His Tag

SKU:  PME-M100026     Target:  VWF

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100025 vwf sp1

ECD Proteins

Mouse VWF (764-2813) Protein, His Tag

SKU:  PME-M100025     Target:  VWF

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100024 vwf sp1

ECD Proteins

Mouse VWF (23-763) Protein, His Tag

SKU:  PME-M100024     Target:  VWF

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100690 vwf sp1

ECD Proteins

Human VWF (23-2813) Protein, His Tag

SKU:  PME100690     Target:  VWF

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100689 cd93 sp1

ECD Proteins

Human CD93 Protein, hFc Tag

SKU:  PME100689     Target:  CD93

Price: 10μg $85.00; 50μg $310.00 ; 100 μg $450.00

sp-pme100688 nucleocapsid sp1

ECD Proteins

SARS-CoV-2 (Omicron) Nucleocapsid, C-His Tag

SKU:  PME100688     Target:  Nucleocapsid

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme d100001 il18bp sp1

ECD Proteins

Canis lupus familiaris IL18BP Protein, hFc Tag

SKU:  PME-D100001     Target:  IL18BP

Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00

sp-pme c100003 il9 sp1

ECD Proteins

Cynomolgus IL9 Protein, hFc Tag

SKU:  PME-C100003     Target:  IL9

Price:10μg $120.00; 50μg $380.00; 100μg $570.00

sp-pme c100002 cxcl10 sp1

ECD Proteins

Cynomolgus CXCL10 Protein, hFc Tag

SKU:  PME-C100002     Target:  CXCL10

Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00

sp-pme c100001 il18bp sp1

ECD Proteins

Cynomolgus IL18BP Protein, hFc Tag

SKU:  PME-C100001     Target:  IL18BP

Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00

sp-pme m100023 rnase4 sp1

ECD Proteins

Mouse RNASE4 Protein, hFc Tag

SKU:  PME-M100023     Target:  RNASE4

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100022 lama4 sp1

ECD Proteins

Mouse LAMA4 Protein, His Tag

SKU:  PME-M100022     Target:  LAMA4

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100021 tenm4 sp1

ECD Proteins

Mouse TENM4 Protein, His Tag

SKU:  PME-M100021     Target:  TENM4

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100020 hbegf sp1

ECD Proteins

Mouse HBEGF (24-160) Protein, His Tag

SKU:  PME-M100020     Target:  HBEGF

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100017 ifnb1 sp1

ECD Proteins

Mouse IFNB1 Protein, His Tag

SKU:  PME-M100017     Target:  IFNB1

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme m100016 gitr sp1

ECD Proteins

Mouse GITR Protein, hFc Tag

SKU:  PME-M100016     Target:  GITR

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100015 cd33 sp1

ECD Proteins

Mouse CD33 Protein, hFc Tag

SKU:  PME-M100015     Target:  CD33

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme m100014 cd138 sp1

ECD Proteins

Mouse CD138 Protein, hFc Tag

SKU:  PME-M100014     Target:  CD138

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00