Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme100063 cldn6 sp1

ECD Proteins

Human CLDN6 Protein, mFc Tag

SKU:  PME100063     Target:  CLDN6

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100758 sparc sp1

ECD Proteins

Human SPARC Protein, hFc Tag

SKU:  PME100758     Target:  SPARC

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100757 gpr55 sp1

ECD Proteins

Human GPR55(1-21) Protein, hFc Tag

SKU:  PME100757     Target:  GPR55

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100756 clec4c sp1

ECD Proteins

Human CLEC4C Protein, hFc Tag

SKU:  PME100756     Target:  CLEC4C

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100755 b7 h3 sp1

ECD Proteins

Human B7-H3 Protein, mFc Tag

SKU:  PME100755     Target:  B7-H3

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100754 mmp9 sp1

ECD Proteins

Human MMP9(20-707) Protein, His Tag

SKU:  PME100754     Target:  MMP9

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100752 tnfsf15 sp1

ECD Proteins

Human TNFSF15 Protein, hFc Tag

SKU:  PME100752     Target:  TNFSF15

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100751 cd142 sp1

ECD Proteins

Human CD142 Protein, hFc Tag

SKU:  PME100751     Target:  CD142

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100750 prlr sp1

ECD Proteins

Human PRLR Protein, hFc Tag

SKU:  PME100750     Target:  PRLR

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100749 emcn sp1

ECD Proteins

Human EMCN Protein, hFc Tag

SKU:  PME100749     Target:  EMCN

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100748 il1r2 sp1

ECD Proteins

Human IL1R2 Protein, His Tag

SKU:  PME100748     Target:  IL1R2

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100747 rage sp1

ECD Proteins

Human RAGE Protein, His Tag

SKU:  PME100747     Target:  RAGE

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100746 il1rap sp1

ECD Proteins

Human IL1RAP Protein, His Tag

SKU:  PME100746     Target:  IL1RAP

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100740 clec2d sp1

ECD Proteins

Human CLEC2D Protein, His Tag

SKU:  PME100740     Target:  CLEC2D

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100714 hsd17b10 sp1

ECD Proteins

Human HSD17B10 Protein, S Tag

SKU:  PME100714     Target:  HSD17B10

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-PME100296 IL17RB His PAGE 300

ECD Proteins

Human IL17RB Protein, His Tag

SKU:  PME100296     Target:  IL17RB

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100745 lilrb2 sp1

ECD Proteins

Human LILRB2 Protein, His Tag

SKU:  PME100745     Target:  LILRB2

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme d100002 anxa2 sp1

ECD Proteins

Canis lupus familiaris ANXA2 Protein, His Tag

SKU:  PME-D100002     Target:  ANXA2

Price:10μg $95.00; 50μg $330.00; 100μg $500.00

sp-pme100744 lif sp1

ECD Proteins

Human LIF Protein, hFc Tag

SKU:  PME100744     Target:  LIF

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100743 cd63 sp1

ECD Proteins

Human CD63 Protein, hFc Tag

SKU:  PME100743     Target:  CD63

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100741 adgre2 sp1

ECD Proteins

Human ADGRE2 Protein, His Tag

SKU:  PME100741     Target:  ADGRE2

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100739 il31 sp1

ECD Proteins

Human IL31 Protein, hFc Tag

SKU:  PME100739     Target:  IL31

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100738 mdk sp1

ECD Proteins

Human MDK Protein, hFc Tag

SKU:  PME100738     Target:  MDK

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100737 ifnar1 sp1

ECD Proteins

Human IFNAR1 Protein, mFc Tag

SKU:  PME100737     Target:  IFNAR1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100736 ret sp1

ECD Proteins

Human RET Protein, His Tag

SKU:  PME100736     Target:  RET

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100735 muc18 sp1

ECD Proteins

Human MUC18 Protein, His Tag

SKU:  PME100735     Target:  MUC18

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100734 lrig1 sp1

ECD Proteins

Human LRIG1 Protein, His Tag

SKU:  PME100734     Target:  LRIG1

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100733 zp3 sp1

ECD Proteins

Human ZP3 Protein, His Tag

SKU:  PME100733     Target:  ZP3

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100729 tmigd2 sp1

ECD Proteins

Human TMIGD2 Protein, hFc Tag

SKU:  PME100729     Target:  TMIGD2

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100728 prnp sp1

ECD Proteins

Human PRNP(90-230) Protein, hFc Tag

SKU:  PME100728     Target:  PRNP

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100727 prnp sp1

ECD Proteins

Human PRNP Protein, hFc Tag

SKU:  PME100727     Target:  PRNP

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100726 flt1 sp1

ECD Proteins

Human FLT1 Protein, His Tag

SKU:  PME100726     Target:  FLT1

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00