Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme100725 adam8 sp1

ECD Proteins

Human ADAM8 Protein, His Tag

SKU:  PME100725     Target:  ADAM8

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100724 mesothelin sp1

ECD Proteins

Human Mesothelin(37-286) Protein, His Tag

SKU:  PME100724     Target:  Mesothelin

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100723 tem1 sp1

ECD Proteins

Human TEM1 Protein, His Tag

SKU:  PME100723     Target:  TEM1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100711 mmp9 sp1

ECD Proteins

Human MMP9(20-469) Protein, His Tag

SKU:  PME100711     Target:  MMP9

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme c100009 mdk sp1

ECD Proteins

Cynomolgus MDK Protein, hFc Tag

SKU:  PME-C100009     Target:  MDK

Price: 10μg $120.00 ; 50μg $409.00 ; 100 μg $615.00

sp-pme c100010 ccl24 sp1

ECD Proteins

Cynomolgus CCL24 Protein, hFc Tag

SKU:  PME-C100010     Target:  CCL24

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme m100036 stab1 sp1

ECD Proteins

Mouse STAB1 Protein, His Tag

SKU:  PME-M100036     Target:  STAB1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100034 ccr8 sp1

ECD Proteins

Mouse CCR8 Protein, hFc Tag

SKU:  PME-M100034     Target:  CCR8

Price: 10μg $100.00; 50μg $366.00 ; 100 μg $549.00

sp-pme m100033 cd93 sp1

ECD Proteins

Mouse CD93 Protein, His Tag

SKU:  PME-M100033     Target:  CD93

Price: 10μg $85.00; 50μg $310.00 ; 100 μg $450.00

sp-pme100722 gcgr sp1

ECD Proteins

Human GCGR Protein, hFc Tag

SKU:  PME100722     Target:  GCGR

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100721 adam28 sp1

ECD Proteins

Human ADAM28 Protein, His Tag

SKU:  PME100721     Target:  ADAM28

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100720 npc1l1 sp1

ECD Proteins

Human NPC1L1 Protein, His Tag

SKU:  PME100720     Target:  NPC1L1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100719 stab1 sp1

ECD Proteins

Human STAB1 Protein, His Tag

SKU:  PME100719     Target:  STAB1

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100718 stab1 sp1

ECD Proteins

Human STAB1 Protein, hFc Tag

SKU:  PME100718     Target:  STAB1

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100717 itga2itgb1 sp1

ECD Proteins

Human ITGA2 and ITGB1 Heterodimer Protein, His Tag and hFc Tag

SKU:  PME100717     Target:  ITGA2;ITGB1

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100716 cd235a sp1

ECD Proteins

Human CD235A Protein, hFc Tag

SKU:  PME100716     Target:  CD235A

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100715 scube2 sp1

ECD Proteins

Human SCUBE2(441-659) Protein, hFc Tag

SKU:  PME100715     Target:  SCUBE2

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100713 hpse sp1

ECD Proteins

Human HPSE Protein, His Tag

SKU:  PME100713     Target:  HPSE

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100712 hsp90aa1 sp1

ECD Proteins

Human HSP90AA1 Protein, His Tag

SKU:  PME100712     Target:  HSP90AA1

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100710 dap10 sp1

ECD Proteins

Human DAP10 Protein, hFc Tag

SKU:  PME100710     Target:  DAP10

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme c100008 anxa2 sp1

ECD Proteins

Cynomolgus ANXA2 Protein, His Tag

SKU:  PME-C100008     Target:  ANXA2

Price: 10μg $95.00 ; 50μg $330.00 ; 100 μg $500.00

sp-pme c100007 cxcl4 sp1

ECD Proteins

Cynomolgus CXCL4 Protein, hFc Tag

SKU:  PME-C100007     Target:  CXCL4

Price: 10μg $120.00 ; 50μg $409.00 ; 100 μg $615.00

sp-pme100311 itgb1 sp1

ECD Proteins

Human ITGB1 Protein, hFc Tag

SKU:  PME100311     Target:  ITGB1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100228 cxcr7 sp1

ECD Proteins

Human CXCR7 Protein, hFc Tag

SKU:  PME100228     Target:  CXCR7

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme c100006 ccr8 sp1

ECD Proteins

Cynomolgus CCR8 Protein, hFc Tag

SKU:  PME-C100006     Target:  CCR8

Price: 10μg $100.00 ; 50μg $375.00 ; 100 μg $550.00

sp-pme100706 itga2 sp1

ECD Proteins

Human ITGA2 Protein, His Tag

SKU:  PME100706     Target:  ITGA2

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme101031 vegfa sp1

ECD Proteins

Human VEGFA Protein, hFc Tag

SKU:  PME101031     Target:  VEGFA

Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00

sp-pme m100032 rnase4 sp1

ECD Proteins

Mouse RNASE4 Protein, His Tag

SKU:  PME-M100032     Target:  RNASE4

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme m100031 mmp13 sp1

ECD Proteins

Mouse MMP13 Protein, His Tag

SKU:  PME-M100031     Target:  MMP13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100030 mmp13 sp1

ECD Proteins

Mouse MMP13 Protein, hFc Tag

SKU:  PME-M100030     Target:  MMP13

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme m100029 cd7 sp1

ECD Proteins

Mouse CD7 Protein, hFc Tag

SKU:  PME-M100029     Target:  CD7

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme m100028 pglyrp1 sp1

ECD Proteins

Mouse PGLYRP1 Protein, hFc Tag

SKU:  PME-M100028     Target:  PGLYRP1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00