Extracellular Domain Protein (ECD)

DIMA BIOTECH offers over 1000 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Hot Duggable Targets

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

pages-416107bc534d939 1

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

pages-cvsdvdfffffb 1

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

ECD Proteins

sp-pme100631 ephb2 sp1

ECD Proteins

Human EPHB2 Protein, His Tag

SKU:  PME100631     Target:  EPHB2

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100625 fcrl5 sp1

ECD Proteins

Human FCRL5 Protein, His Tag

SKU:  PME100625     Target:  FCRL5

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100624 epha4 sp1

ECD Proteins

Human EPHA4 Protein, His Tag

SKU:  PME100624     Target:  EPHA4

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100621 gfral sp1

ECD Proteins

Human GFRAL Protein, His Tag

SKU:  PME100621     Target:  GFRAL

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100630 ror1 sp1

ECD Proteins

Human ROR1 (312-391) Protein, hFc Tag

SKU:  PME100630     Target:  ROR1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100629 uchl1 sp1

ECD Proteins

Human UCHL1 Protein, hFc Tag

SKU:  PME100629     Target:  UCHL1

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100628 gdf15 sp1

ECD Proteins

Human GDF15 Protein, hFc Tag

SKU:  PME100628     Target:  GDF15

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100627 il17c sp1

ECD Proteins

Human IL17C Protein, hFc Tag

SKU:  PME100627     Target:  IL17C

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-PME100626 FAP His PAGE 300 1

ECD Proteins

Human FAP (30-760) Protein, His Tag

SKU:  PME100626     Target:  FAP

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100622 adgre1 sp1

ECD Proteins

Human ADGRE1 Protein, His Tag

SKU:  PME100622     Target:  ADGRE1

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100620 gfra3 sp1

ECD Proteins

Human GFRA3 Protein, His Tag

SKU:  PME100620     Target:  GFRA3

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100634 mmp9 sp1

ECD Proteins

Human MMP9(107-707) Protein, His Tag

SKU:  PME100634     Target:  MMP9

Price: 10μg $120.00 ; 50μg $450.00 ; 100 μg $660.00

sp-pme100618 fzd4 sp1

ECD Proteins

Human FZD4 Protein, hFc Tag

SKU:  PME100618     Target:  FZD4

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100617 ereg sp1

ECD Proteins

Human EREG Protein, hFc Tag

SKU:  PME100617     Target:  EREG

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme101042 dkk2 sp1

ECD Proteins

Human DKK2 Protein, hFc Tag

SKU:  PME101042     Target:  DKK2

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-PME100849 CD9 Fig.1 SDS PAGE 1

ECD Proteins

Human CD9 Protein, His Tag

SKU:  PME100849     Target:  CD9

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100613 efna3 sp1

ECD Proteins

Human EFNA3 Protein, hFc Tag

SKU:  PME100613     Target:  EFNA3

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100611 cxcl4 sp1

ECD Proteins

Human CXCL4 Protein, hFc Tag

SKU:  PME100611     Target:  CXCL4

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100610 clec9a sp1

ECD Proteins

Human CLEC9A Protein, hFc Tag

SKU:  PME100610     Target:  CLEC9A

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-PME100609 CLEC1A hFc PAGE 300

ECD Proteins

Human CLEC1A Protein, hFc Tag

SKU:  PME100609     Target:  CLEC1A

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-PME100608 CHODL hFc PAGE 300

ECD Proteins

Human CHODL Protein, hFc Tag

SKU:  PME100608     Target:  CHODL

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100607 dll3 sp1 1

ECD Proteins

Human DLL3 Protein, hFc Tag

SKU:  PME100607     Target:  DLL3

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100606 cd69 sp1 1

ECD Proteins

Human CD69 Protein, hFc Tag

SKU:  PME100606     Target:  CD69

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100605 crtam sp1

ECD Proteins

Human CRTAM Protein, His Tag

SKU:  PME100605     Target:  CRTAM

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100615 epha5 sp1

ECD Proteins

Human EPHA5 Protein, His Tag

SKU:  PME100615     Target:  EPHA5

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100616 antxr1 sp1

ECD Proteins

Human ANTXR1 Protein, His Tag

SKU:  PME100616     Target:  ANTXR1

Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00

sp-pme100601 mdr 1 sp1

ECD Proteins

Human MDR-1 (72-113) Protein, hFc Tag

SKU:  PME100601     Target:  MDR-1

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100600 cd68 sp1

ECD Proteins

Human CD68 Protein, His Tag

SKU:  PME100600     Target:  CD68

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100599 cd5l sp1

ECD Proteins

Human CD5L Protein, His Tag

SKU:  PME100599     Target:  CD5L

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

sp-pme100598 upa sp1

ECD Proteins

Human UPA Protein, His Tag

SKU:  PME100598     Target:  UPA

Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00

sp-pme100450 tyro3 sp1

ECD Proteins

Human TYRO3 Protein, His Tag

SKU:  PME100450     Target:  TYRO3

Price: 10μg $72.00; 50μg $272.00; 100μg $409.00

sp-pme100350 mif sp1

ECD Proteins

Human MIF Protein, hFc Tag

SKU:  PME100350     Target:  MIF

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00