DIMA Biotech’s Synthetic Nanodiscs offer a powerful solution for advancing membrane protein research and drug discovery. Our polymer-based nanodisc platform stabilizes and purifies full-length multi-pass membrane proteins without the use of membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences in downstream assays. We’ve successfully developed over 500 off-the-shelf Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters. Our portfolio includes high-complexity proteins such as the 24-pass transmembrane ion channel protein SCN5A (Cat. No. FLP100726), showcasing our deep expertise in working with difficult membrane proteins. Explore how our Synthetic Nanodiscs enable reliable purification and functional analysis of membrane proteins in their native-like form.
Explore Our Nanodisc Collection!
Price: 10 μg $630.00; 50 μg $3080.00; 100 μg $5600.00
SKU: FLP100000
Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein
Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE
Flagged tagged SLC7A11-Nanodisc (FLP100048) can bind anti-Flag mAb and the EC50 is 4.101ng/ml.
The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.
Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein
Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE
Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).
Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.
Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein
Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE
MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.
Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein
Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE
GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.
ELISA
Lyophilization test
Accelerated Test (Lyophilized Powder)
Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins
Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Protein crystal structure analysis
Full Length Transmembrane Proteins
SKU: FLP120300 Target: GPR26
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
Full Length Transmembrane Proteins
SKU: FLP120216 Target: CALCR
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
