Synthetic Nanodisc: An Innovative Solution For Multipass Transmembrane Proteins

Discover a breakthrough in membrane protein research and drug development with DIMA Biotech’s Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing solution by excluding membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences for downstream assays. By disassembling cell membranes into nanoscale disc-shaped structures, our technology enables the purification of membrane proteins to high homogeneity under aqueous conditions. Explore how Synthetic Nanodiscs empower the functional characterization of multi-span transmembrane proteins in their active form, revolutionizing the future of membrane protein research and drug development.

Explore Our Nanodisc Collection!

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

page-FLP100014 CLDN18.2 Fig.2 SDS PAGE 1

Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

pages-Full length Membrane Proteins High Activity High Stability 4

High Stability

Lyophilization test

pages-Full length Membrane Proteins High Activity High Stability 5

Accelerated Test (Lyophilized Powder)

pages-Full length Membrane Proteins High Activity High Stability 6

Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

small-icon-2

Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Cell based assays
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

Request Your Target Protein in Nanodiscs


    Please prove you are human by selecting the flag.

    Synthetic Nanodiscs Products

    Full Length Transmembrane Proteins

    Human TA2R full length protein-synthetic nanodisc

    SKU:  FLP100475     Target:  TA2R

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human T2R60 full length protein-synthetic nanodisc

    SKU:  FLP100474     Target:  T2R60

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human T2R38 full length protein-synthetic nanodisc

    SKU:  FLP100473     Target:  T2R38

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human T2R16 full length protein-synthetic nanodisc

    SKU:  FLP100472     Target:  T2R16

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SUCR1 full length protein-synthetic nanodisc

    SKU:  FLP100471     Target:  SUCR1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SSR5 full length protein-synthetic nanodisc

    SKU:  FLP100470     Target:  SSR5

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SSR4 full length protein-synthetic nanodisc

    SKU:  FLP100469     Target:  SSR4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SSR3 full length protein-synthetic nanodisc

    SKU:  FLP100468     Target:  SSR3

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SSR1 full length protein-synthetic nanodisc

    SKU:  FLP100467     Target:  SSR1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SMO full length protein-synthetic nanodisc

    SKU:  FLP100466     Target:  SMO

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SCTR full length protein-synthetic nanodisc

    SKU:  FLP100465     Target:  SCTR

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human S1PR5 full length protein-synthetic nanodisc

    SKU:  FLP100464     Target:  S1PR5

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00