Synthetic Nanodisc: An Innovative Solution For Multipass Transmembrane Proteins

Discover a breakthrough in membrane protein research and drug development with DIMA Biotech’s Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing solution by excluding membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences for downstream assays. By disassembling cell membranes into nanoscale disc-shaped structures, our technology enables the purification of membrane proteins to high homogeneity under aqueous conditions. Explore how Synthetic Nanodiscs empower the functional characterization of multi-span transmembrane proteins in their active form, revolutionizing the future of membrane protein research and drug development.

Explore Our Nanodisc Collection!

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

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Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

pages-Full length Membrane Proteins High Activity High Stability 4

High Stability

Lyophilization test

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Accelerated Test (Lyophilized Powder)

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Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

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Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Cell based assays
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

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    Synthetic Nanodiscs Products

    Full Length Transmembrane Proteins

    Human CCR2 full length protein-synthetic nanodisc

    SKU:  FLP100028     Target:  CCR2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human CD20 full length protein-synthetic nanodisc

    SKU:  FLP100027     Target:  CD20

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human OR2H1 full length protein-synthetic nanodisc

    SKU:  FLP100025     Target:  OR2H1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human CCR4 full length protein-synthetic nanodisc

    SKU:  FLP100024     Target:  CCR4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human CB1 full length protein-synthetic nanodisc

    SKU:  FLP100023     Target:  CB1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human TM4SF1 full length protein-synthetic nanodisc

    SKU:  FLP100022     Target:  TM4SF1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human ADORA2A full length protein-synthetic nanodisc

    SKU:  FLP100020     Target:  ADORA2A

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human CLDN18.2 full length protein-synthetic nanodisc

    SKU:  FLP100014     Target:  CLDN18.2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human SSTR2 full length protein-synthetic nanodisc

    SKU:  FLP100013     Target:  SSTR2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human GPRC5D full length protein-synthetic nanodisc

    SKU:  FLP100011     Target:  GPRC5D

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Full Length Transmembrane Proteins

    Human CLDN6 full length protein-synthetic nanodisc

    SKU:  FLP100008     Target:  CLDN6

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00