Synthetic Nanodisc: A Polymer-Based Solution for Multipass Transmembrane Proteins

DIMA Biotech’s Synthetic Nanodiscs offer a powerful solution for advancing membrane protein research and drug discovery. Our polymer-based nanodisc platform stabilizes and purifies full-length multi-pass membrane proteins without the use of membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences in downstream assays. We’ve successfully developed over 500 off-the-shelf Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters. Our portfolio includes high-complexity proteins such as the 24-pass transmembrane ion channel protein SCN5A (Cat. No. FLP100726), showcasing our deep expertise in working with difficult membrane proteins. Explore how our Synthetic Nanodiscs enable reliable purification and functional analysis of membrane proteins in their native-like form.

Explore Our Nanodisc Collection!
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elisa-flp100000 negative control elisa1

New: Negative Control – Synthetic Nanodisc

Price: 10 μg $630.00; 50 μg $3080.00; 100 μg $5600.00

SKU: FLP100000

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

page-FLP100048 SLC7A11 Fig.2 SDS PAGE 1

Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100048 SLC7A11 Fig.1 Elisa 1

Flagged tagged SLC7A11-Nanodisc (FLP100048) can bind anti-Flag mAb and the EC50 is 4.101ng/ml.

SPR-flp100048 slc7a11 sec hplc1

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

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Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

ELISA assay to evaluate MDR-1-Nanodisc

MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

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High Stability

Lyophilization test

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Accelerated Test (Lyophilized Powder)

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Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

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Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

The structure of MSP-Nanodisc (left) and Synthetic Nanodisc (right)

Blog

Synthetic Nanodisc, A Promising Solution for “Undruggable” Membrane Proteins

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    Synthetic Nanodiscs Products

    page-FLP100115 CX3CR1 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human CX3CR1 full length protein-synthetic nanodisc

    SKU:  FLP100115     Target:  CX3CR1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100114 F2RL3 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human F2RL3 full length protein-synthetic nanodisc

    SKU:  FLP100114     Target:  F2RL3

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100113 GLP2R Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human GLP2R full length protein-synthetic nanodisc

    SKU:  FLP100113     Target:  GLP2R

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100112 SCARB1 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human SCARB1 full length protein-synthetic nanodisc

    SKU:  FLP100112     Target:  SCARB1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100111 CHRM2 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human CHRM2 full length protein-synthetic nanodisc

    SKU:  FLP100111     Target:  CHRM2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100110 CLPTM1 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLPTM1 full length protein-synthetic nanodisc

    SKU:  FLP100110     Target:  CLPTM1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100109 FZD7 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human FZD7 full length protein-synthetic nanodisc

    SKU:  FLP100109     Target:  FZD7

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100108 GPR20 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human GPR20 full length protein-synthetic nanodisc

    SKU:  FLP100108     Target:  GPR20

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100107 ADGRG2 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human ADGRG2 full length protein-synthetic nanodisc

    SKU:  FLP100107     Target:  ADGRG2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100106 MFSD13A Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human MFSD13A full length protein-synthetic nanodisc

    SKU:  FLP100106     Target:  MFSD13A

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100105 MRGPRX2 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human MRGPRX2 full length protein-synthetic nanodisc

    SKU:  FLP100105     Target:  MRGPRX2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100104 ADGRG1 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human ADGRG1 full length protein-synthetic nanodisc

    SKU:  FLP100104     Target:  ADGRG1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Citation

    [1] Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)