Synthetic Nanodisc: A Polymer-Based Solution for Multipass Transmembrane Proteins

DIMA Biotech’s Synthetic Nanodiscs offer a powerful solution for advancing membrane protein research and drug discovery. Our polymer-based nanodisc platform stabilizes and purifies full-length multi-pass membrane proteins without the use of membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences in downstream assays. We’ve successfully developed over 500 off-the-shelf Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters. Our portfolio includes high-complexity proteins such as the 24-pass transmembrane ion channel protein SCN5A (Cat. No. FLP100726), showcasing our deep expertise in working with difficult membrane proteins. Explore how our Synthetic Nanodiscs enable reliable purification and functional analysis of membrane proteins in their native-like form.

Explore Our Nanodisc Collection!
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elisa-flp100000 negative control elisa1

New: Negative Control – Synthetic Nanodisc

Price: 10 μg $630.00; 50 μg $3080.00; 100 μg $5600.00

SKU: FLP100000

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

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Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100048 SLC7A11 Fig.1 Elisa 1

Flagged tagged SLC7A11-Nanodisc (FLP100048) can bind anti-Flag mAb and the EC50 is 4.101ng/ml.

SPR-flp100048 slc7a11 sec hplc1

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

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Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

ELISA assay to evaluate MDR-1-Nanodisc

MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

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High Stability

Lyophilization test

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Accelerated Test (Lyophilized Powder)

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Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

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Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

The structure of MSP-Nanodisc (left) and Synthetic Nanodisc (right)

Blog

Synthetic Nanodisc, A Promising Solution for “Undruggable” Membrane Proteins

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    Synthetic Nanodiscs Products

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    Full Length Transmembrane Proteins

    Human ADGRE2 full length protein-synthetic nanodisc

    SKU:  FLP100090     Target:  ADGRE2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100089 NPC1L1 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human NPC1L1 full length protein-synthetic nanodisc

    SKU:  FLP100089     Target:  NPC1L1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100088 TSPAN8 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human TSPAN8 full length protein-synthetic nanodisc

    SKU:  FLP100088     Target:  TSPAN8

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100087 MLC1 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human MLC1 full length protein-synthetic nanodisc

    SKU:  FLP100087     Target:  MLC1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100086 C5AR1 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human C5AR1 full length protein-synthetic nanodisc

    SKU:  FLP100086     Target:  C5AR1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100085 GCGR Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human GCGR full length protein-synthetic nanodisc

    SKU:  FLP100085     Target:  GCGR

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100084 SLC2A12 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human SLC2A12 full length protein-synthetic nanodisc

    SKU:  FLP100084     Target:  SLC2A12

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100083 CLDN4 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLDN4 full length protein-synthetic nanodisc

    SKU:  FLP100083     Target:  CLDN4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100082 CLDN2 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLDN2 full length protein-synthetic nanodisc

    SKU:  FLP100082     Target:  CLDN2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100081 CLDN9 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLDN9 full length protein-synthetic nanodisc

    SKU:  FLP100081     Target:  CLDN9

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100079 CLDN5 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLDN5 full length protein-synthetic nanodisc

    SKU:  FLP100079     Target:  CLDN5

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100078 CLDN3 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CLDN3 full length protein-synthetic nanodisc

    SKU:  FLP100078     Target:  CLDN3

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Citation

    [1] Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)