Synthetic Nanodisc: A Polymer-Based Solution for Multipass Transmembrane Proteins

DIMA Biotech’s Synthetic Nanodiscs offer a powerful solution for advancing membrane protein research and drug discovery. Our polymer-based nanodisc platform stabilizes and purifies full-length multi-pass membrane proteins without the use of membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences in downstream assays. We’ve successfully developed over 500 off-the-shelf Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters. Our portfolio includes high-complexity proteins such as the 24-pass transmembrane ion channel protein SCN5A (Cat. No. FLP100726), showcasing our deep expertise in working with difficult membrane proteins. Explore how our Synthetic Nanodiscs enable reliable purification and functional analysis of membrane proteins in their native-like form.

Explore Our Nanodisc Collection!
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elisa-flp100000 negative control elisa1

New: Negative Control – Synthetic Nanodisc

Price: 10 μg $630.00; 50 μg $3080.00; 100 μg $5600.00

SKU: FLP100000

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

page-FLP100048 SLC7A11 Fig.2 SDS PAGE 1

Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100048 SLC7A11 Fig.1 Elisa 1

Flagged tagged SLC7A11-Nanodisc (FLP100048) can bind anti-Flag mAb and the EC50 is 4.101ng/ml.

SPR-flp100048 slc7a11 sec hplc1

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

page-FLP100014 CLDN18.2 Fig.2 SDS PAGE 1

Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

ELISA assay to evaluate MDR-1-Nanodisc

MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

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High Stability

Lyophilization test

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Accelerated Test (Lyophilized Powder)

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Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

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Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

The structure of MSP-Nanodisc (left) and Synthetic Nanodisc (right)

Blog

Synthetic Nanodisc, A Promising Solution for “Undruggable” Membrane Proteins

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    Synthetic Nanodiscs Products

    page-FLP100075 CCR3 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human CCR3 full length protein-synthetic nanodisc

    SKU:  FLP100075     Target:  CCR3

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100074 CXCR4 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CXCR4 full length protein-synthetic nanodisc

    SKU:  FLP100074     Target:  CXCR4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100073 LGR5 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human LGR5 full length protein-synthetic nanodisc

    SKU:  FLP100073     Target:  LGR5

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100072 LGR4 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human LGR4 full length protein-synthetic nanodisc

    SKU:  FLP100072     Target:  LGR4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100071 CD151 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CD151 full length protein-synthetic nanodisc

    SKU:  FLP100071     Target:  CD151

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100070 STEAP1 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human STEAP1 full length protein-synthetic nanodisc

    SKU:  FLP100070     Target:  STEAP1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100069 GPR77 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human C5AR2 full length protein-synthetic nanodisc

    SKU:  FLP100069     Target:  C5AR2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100068 LGR6 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human LGR6 full length protein-synthetic nanodisc

    SKU:  FLP100068     Target:  LGR6

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100067 CXCR5 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CXCR5 full length protein-synthetic nanodisc

    SKU:  FLP100067     Target:  CXCR5

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100066 CXCR2 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CXCR2 full length protein-synthetic nanodisc

    SKU:  FLP100066     Target:  CXCR2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100065 CD39 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CD39 full length protein-synthetic nanodisc

    SKU:  FLP100065     Target:  CD39

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100064 SLC2A4 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human SLC2A4 full length protein-synthetic nanodisc

    SKU:  FLP100064     Target:  SLC2A4

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Citation

    [1] Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)