Synthetic Nanodisc: A Polymer-Based Solution for Multipass Transmembrane Proteins

DIMA Biotech’s Synthetic Nanodiscs offer a powerful solution for advancing membrane protein research and drug discovery. Our polymer-based nanodisc platform stabilizes and purifies full-length multi-pass membrane proteins without the use of membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences in downstream assays. We’ve successfully developed over 500 off-the-shelf Nanodisc proteins, covering a wide range of challenging targets such as GPCRs, ion channels, and transporters. Our portfolio includes high-complexity proteins such as the 24-pass transmembrane ion channel protein SCN5A (Cat. No. FLP100726), showcasing our deep expertise in working with difficult membrane proteins. Explore how our Synthetic Nanodiscs enable reliable purification and functional analysis of membrane proteins in their native-like form.

Explore Our Nanodisc Collection!
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elisa-flp100000 negative control elisa1

New: Negative Control – Synthetic Nanodisc

Price: 10 μg $630.00; 50 μg $3080.00; 100 μg $5600.00

SKU: FLP100000

Case Studies

Human SLC7A11 full length protein-synthetic nanodisc (Cat# FLP100048) 12 pass transmembrane protein

page-FLP100048 SLC7A11 Fig.2 SDS PAGE 1

Human SLC7A11-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100048 SLC7A11 Fig.1 Elisa 1

Flagged tagged SLC7A11-Nanodisc (FLP100048) can bind anti-Flag mAb and the EC50 is 4.101ng/ml.

SPR-flp100048 slc7a11 sec hplc1

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

page-FLP100014 CLDN18.2 Fig.2 SDS PAGE 1

Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

ELISA assay to evaluate MDR-1-Nanodisc

MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

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High Stability

Lyophilization test

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Accelerated Test (Lyophilized Powder)

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Synthetic Nanodiscs

Nanodisc Platform

The diagram of nanodisc

Advantages:
・Full length membrane proteins with high purity
・High solubility in aqueous solutions
・High stability, lyophilized powder stable at room temperature 
・Proteins are in a native membrane environment and remain biologically active
・No detergent, useful for cell-based assays
・No MSP backbone proteins

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Applications:
・ELISA
・SPR affinity analysis
・Phage display screening
・Immunization
・Protein crystal structure analysis

Nanodiscs Products & Service

Off-the-shelf Nanodisc Proteins

The structure of MSP-Nanodisc (left) and Synthetic Nanodisc (right)

Blog

Synthetic Nanodisc, A Promising Solution for “Undruggable” Membrane Proteins

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    Synthetic Nanodiscs Products

    elisa-FLP100049 P2RX7 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human P2RX7 full length protein-synthetic nanodisc

    SKU:  FLP100049     Target:  P2RX7

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100048 SLC7A11 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human SLC7A11 full length protein-synthetic nanodisc

    SKU:  FLP100048     Target:  SLC7A11

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100047 FSHR Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human FSHR full length protein-synthetic nanodisc

    SKU:  FLP100047     Target:  FSHR

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100046 PROM1 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human PROM1 full length protein-synthetic nanodisc

    SKU:  FLP100046     Target:  PROM1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100045 TSHR Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human TSHR full length protein-synthetic nanodisc

    SKU:  FLP100045     Target:  TSHR

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100044 CD36 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CD36 full length protein-synthetic nanodisc

    SKU:  FLP100044     Target:  CD36

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100043 STEAP2 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human STEAP2 full length protein-synthetic nanodisc

    SKU:  FLP100043     Target:  STEAP2

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100042 CD37 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human CD37 full length protein-synthetic nanodisc

    SKU:  FLP100042     Target:  CD37

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100041 PVRIG Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human PVRIG full length protein-synthetic nanodisc

    SKU:  FLP100041     Target:  PVRIG

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    page-FLP100040 STING1 Fig.2 SDS PAGE 1

    Full Length Transmembrane Proteins

    Human STING1 full length protein-synthetic nanodisc

    SKU:  FLP100040     Target:  STING1

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    elisa-FLP100039 CD47 Fig.1 Elisa 1

    Full Length Transmembrane Proteins

    Human CD47 full length protein-synthetic nanodisc

    SKU:  FLP100039     Target:  CD47

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    SPR-FLP100037 CCR8 Fig.3 SPR 1

    Full Length Transmembrane Proteins

    Human CCR8 full length protein-synthetic nanodisc

    SKU:  FLP100037     Target:  CCR8

    Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

    Citation

    [1] Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)